T Cell-Mediated Immunity

Question 1

What does the T cell need to recognise on the dendritic cell to become activated?

Answer 1

The complex of a peptide antigen and a MHC molecule on a dendritic cell (APC)

Question 2

What is the role of effector T cells?

Answer 2

Some remain in the secondary lymphoid tissue to help B cells to become antibody producing cells
Others travel to sites of infection where they work in various ways to terminate infection

Question 3

What is the first stage of a primary adaptive immune response?

Answer 3

T-cell activation

Question 4

Where is the T cell response to infections of the skin and peripheral tissues made?

Answer 4

Draining lymph nodes

Question 5

Where does the T cell response to blood infections happen?

Answer 5

In the spleen

Question 6

What are dendritic cells in the skin and other peripheral tissues called?

Answer 6

Immature dendritic cells

Question 7

What is the function of dendritic cells?

Answer 7

Transport pathogens and their antigens from the site of infection to the T-cell areas of the draining lymph node

Question 8

Why does IgM have limited tissue penetration?

Answer 8

it is a pentamer

Question 9

What two signals are required to stimulate a naive CD8 T cell to differentiate into a cytotoxic T cell?

Answer 9

MHC Class 1 on the dendritic cell (containing peptides from the pathogen) binding to the T cell receptor
B7 on the dendritic cell binds to CD28 on the naive T cell