T cell mediated immunity Flashcards
what do dendritic cells do
carry antigens from sites of infection to secondary lymphoid tissues
do dendritic cells change shape as they circulate
yes
what is required by the activation of naive T cells
signals from the antigen receptor and a co-stimulatory receptor
what molecules are co-stimulation delivered by
professional APCs (dendritic cells, macrophages, and B cells
when is B7 receptor expression induced
during an infection
how are immunological synapses arranged
supramolecular activation complex
with a peripheral portion of it and a central portion
what does clustering the TCR and co-receptor results in
signalling
that pathway chart is next and i refuse to know it so good luck yall o7
what is made by the T cell itself and drives clonal expansion
IL-2
IL2 qualitites
powerful cytokine, highly regulated in time and space, co-stimulation required for production, induces alpha chain of the receptor regulated
which cells are made from the activation of naive CD4 T cells
Th1, Th17, Th2, Tfh cells, Treg cells
he wants us to know the diagram on slide 32 and im too lazy
what is an important CD8 cytotoxic cell and what does it do
perforin, kill virus infected cells
what is an important Th1 cell and what does it do
interferon gamma, help macrophages to suppress intracellular infections
what is an important Th2 cell and what does it do
interleukin 4, help basophils, mast cells, eosinophils, and B cells respond to parasite infections
