immunity mediated by B cells and antibodies Flashcards
what are ITAMs
immunoreceptor tyrosine-based activation motifs
what do ITAMS do
clustering of antigen receptors allows receptor-associated kinases to phosphorylate the ITAMS, then Syk binds to double phosphorylated ITAMS and is activated on binding, activating signal changes to gene expression in the nucleus
B cell activation steps from signals of B cell co-receptor
binding of CR1 to C3b bound to a pathogen facilitates its cleavage by factor I to give iC3b and C3d, the CR2 compound of the B cell co-receptor can then bind to C3d
when B-cell receptor and co-receptor cooperate in B-cell activation by a soluble antigen increases the signaling strength by 1000-10000 fold: T or F
true
does effective B cell mediated immunity depend on help from CD4 Tfh cells (im so sorry but the diagram for this slide is a lost cause from me)
yes
do cytokines made by Tfh cells guide B cell switching of their immunoglobulin isotype?
yes
what kind of mechanism does IgE provide
rapid ejection of parasites and pathogens from the body via mast cells, basophils and activated eosinophils
what does āFcā mean when it is before an a symbol(?)
it links an antibody to the surface of the cell, whatever the next part means which antibody it binds to
is IgE Fc region a high affinity receptor
yes
what is the extremely rapid response designed for
a much larger parasitic infections
what do fcgamma receptors enable in hematopoietic cells
the ability to bind and be activated by IgG bound to pathogens
where are antibodies for ligands for Fc receptors found on
neutrophils, eosinophils, basophils, mast cells, macrophages, follicular dendritic cells, and NK cells
are Fc gamma receptors structurally and functionally distinct from FcRn
yes
what is the major function of FcgammaRI
facilitate uptake and degradation by phagocytes and APCs
what is the only Fc receptor expressed on NK cells
FcgammaR3
