T and B cell Development

Question 1

What enzymes are needed for BCR production?

Answer 1

The same ones for TCR production.

Question 2

Which gene segments make a heavy chain?

Answer 2

V, D, and J. The C segment makes a constant region of the heavy chain; Determines isotype.

Question 3

Which gene segments make a light chain?

Answer 3

V and J make the variable region of the light chain. C makes the constant region of the light chain.

Question 4

Where do Immature B cells go to finish maturation?

Answer 4

The spleen and lymph nodes.

Question 5

What the difference between immature B cells and mature B cells in terms of activation?

Answer 5

Mature B cells are activated by high affinity binding to antigens; These cells are allowed to multiply. Others die by apoptosis.

Question 6

Know B cell maturation chart

Answer 6

Pg 65

Question 7

Where are T-independent B cells?

Answer 7

Marginal zone and B1 cells; Activated by non protein antigens. Early stages of adaptive response.

Question 8

What is the role of the Marginal zone and B1 cells?

Answer 8

Produce natural antibodies; Low affinity for carbohydrate antigens (gut microflora) and antibodies against blood group antigens.

Question 9

Compare TCRs to BCRs

Answer 9

Chart pg 67