T 21

Question 1

Why is TMS (tetramethylsilane) often used as an internal reference standard for the calibration of HNMR spectroscopy?

Answer 1

• chemical shift/signal outside range of common chemical shift/signal
• strong signal (all (12) H atoms in same environment)
• singlet/no splitting of signal
• volatile/easy to remove/easily separated
• inert/stable
• soluble in most organic solvents