Systemic Sclerosis/Scleroderma

Question 1

What are the two types of systemic sclerosis?

Answer 1

Limited cutaneous

Diffuse cutaneous

Question 2

Features of limited cutaneous systemic sclerosis (5)

Answer 2

CREST

C-Calcinosis (calcium deposits)
R-Raynaud’s
E-oEsophageal dysmotility 
S-Sclerodactyly (hardening of skin causing claw hand)
T-Telangiectasia (spider veins)

Question 3

Complications of diffuse cutaneous systemic sclerosis affect what systems (3)

Answer 3

Cardiovascular problems
Respiratory problems
Kidney problems

Question 4

What are the autoantibody seen in systemic sclerosis

Answer 4

Anti-nuclear

Question 5

What is the antibody seen in diffuse cutaneous and the antibody seen in limited cutaneous systemic sclerosis

Answer 5

Limited-Anti centromere

Diffuse-Anti SCL 70

Question 6

What investigation is used for systemic sclerosis

Answer 6

Nailfold capillaroscopy

Question 7

Primary treatment of Systemic sclerosis (2)

Answer 7

Steroids

Immunosuppressants