SLE Flashcards
1
Q
What autoantibodies are seen in SLE? (2)
A
Anti-nuclear
Anti-dsDNA
2
Q
SLE presentation (any 5)
A
Fatigue Weight loss Arthralgia Myalgia Fever Butterfly rash that gets worse in sunlight Lymphadenopathy Splenomegaly SOB Mouth ulcers Hair loss Raynaud’s
3
Q
Investigations for SLE (7)
A
Autoantibodies FBC C3 and C4 CRP and ESR Raised immunoglobulins Urinalysis and urine protein:creatinine ratio (lupus nephritis) Renal biopsy (lupus nephritis)
4
Q
What 2 scoring systems are used to diagnose SLE?
A
SLICC
ACR
5
Q
Complications of SLE (any 5)
A
CVD Infection Anaemia of chronic disease Pericarditis Pleuritis ILD Lupus nephritis Recurrent miscarriage VTE (secondary to antiphosphoplipid syndrome) Antiphospholipid syndrome
6
Q
First line treatment of SLE (4)
A
NSAIDS
Steroids
Hydroxychoroquine
Sunscreen
7
Q
What is the second line treatment for SLE
A
Immunosuppressants
8
Q
What are the biologics used in SLE? (2)
A
Rituximab
Belimumab
