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Surgery A > Systemic Response To Injury > Flashcards

Systemic Response To Injury Flashcards

1
Q

Effects of cortisol

A 
Hepatic gluconeogenesis 
Induces insulin resistance 
Protein degradation 
Lactate release
Mobilization of fatty acids
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2
Q

What does cortisol potentiate

A

Glucagon and epinephrine

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3
Q

How does cortisol affect wound healing

A

TGF

IGF 1

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4
Q

Examples of pro inflammatory mediators

A

TNF-a
IL 1
IL 6

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5
Q

Function of Macrophage inhibitory factor

A

Reverse immunosuppressive effects of glucocorticoid

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6
Q

Function of growth hormone

A

Increase the following

Protein synthesis
Insulin resistance
Mobilization of FA storage

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7
Q

Function of epinephrine

A

Hepatic Glycogenolysis, gluconeogenesis, lipolysis and ketone

Decrease insulin and glucagon secretion

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8
Q

Mineralocorticoid that is released from the adrenal zona glomerulosa

A

Aldosterone

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9
Q

Function of aldosterone

A

Conserve sodium

Eliminate potassium and hydrogen ions

Acts on DCT

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10
Q

Manifestation of excess aldosterone

A

Hypertension

Edema

Hypokalemia

Metabolic alkalosis

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11
Q

Types of inflammatory mediators

A 
HSP
Reactive oxygen metabolite 
Eicosanoid
FA metabolite
Kallikrein-kinin system 
Serotonin 
Histamine 
Cytokines
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12
Q

Function of HSP

A

Induce hypoxia, trauma, heavy metals and hemorrhage

Protect cells

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13
Q

What are the oxygen scavengers

A

Gluthatione

Catalase

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14
Q

Potent vasodilator from the kallikrein-kinin system

A

Bradykinin

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15
Q

Function of kinins

A 
Causes edema
Pain
Inhibit gluconeogenesis 
Renal vasodilation 
Increase bronchi constriction
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16
Q

What type of histamine inhibits its release

A

H2

17
Q

This is the most potent mediator of inflammation

A

Cytokines

18
Q

What interleukin promotes B endorphin release

A

Interleukin 1

19
Q

Seen in acute lung inflammation

A

Interferon gamma

Surgery A (9 decks)

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