Systemic Mycoses

Question 1

Systemic Mycosese
What do they cause?
Type of fungi?
Treatment: local vs systemic

Answer 1

Pulm infections and disseminate; cause granuloma formation; can’t be tranmitted from person to person

Dimorphic Fungi
cold (20C) - mold; heat (37.5C) - yeast

local - fluconazole or itraconazole
Systemic - amphotericin B

Question 2

Histoplasmosis

Endemic Location & carrier
Pathlogic features
unique sign/sx
dx

Answer 2

Mississippi/Ohio river valley; bats&birds droppings

small oval yeast w/in macrophage

palatal/tongue ulcers; splenomegaly

dx via urine/serum antigen

Question 3

Blastomycosis

Endemic Location
Pathologic features
unique sign/sx

Answer 3

E/Central USA

broad based budding (same size RBC)

Inflammatory Lung Disease –> bone/skin
verrucous skin lesions can cause SCC
forms granulomatous nodule

Question 4

Coccidioidomycosis

Endemic Location
Pathologic features
unique sign/sx

Answer 4

SW USA

spherule w/ endospores

pulm syndrome –> meningitis & bone
erythema nodosum/multiforme
Arthralgias (“desert rheumatism”)

Question 5

Para-coccidioidomycosis

Endemic Location
Pathologic features
unique sign/sx

Answer 5

Latin America

Budding yeast w/ “captain wheel” formation

p/w similar to blastomycosis