Systemic Lupus Erythematosus Flashcards
What are anti-nuclear antibodies? How are they detected and reported? What diseases is it associated with?
What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.
What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.
What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.
What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.
How would you define SLE?
Multisystem inflammatory autoimmune disease characterised by autoantibody production of ANA+ve, Anti-DsDNA + C3C4, AntiRO, AntiSm(ith).
What antibodies in SLE are most associated with SLE?
AntiSM (most)
AntiDS DNA
What is the effect of AntiRo in an SLE patient when it crosses the placenta?
Which SLE antibody is also common in Sjogren’s?
AntiRO
How are Anti-DsDNA and C3C4 related in SLE?
What drugs can cause drug induced lupus? What Ab is present?
What is the gender distribution of SLE?
Describe the pathophysiology of SLE.
What are the systemic symptoms of SLE?
What organ systems are affected by SLE?
Skin and mucosa
joints
CNS
Cardio
Resp
Immune
Haematological (BM)
Renal
What are the manifestations of SLE based on the organ system:
1. Skin and mucosa
What are the manifestations of SLE based on the organ system:
1. Joint
What are the manifestations of SLE based on the organ system:
1. CNS
What are the manifestations of SLE based on the organ system:
1. Cardio
What are the manifestations of SLE based on the organ system:
1. Resp
What are the manifestations of SLE based on the organ system:
1. Immune
What are the manifestations of SLE based on the organ system:
1. Haematology
What are the manifestations of SLE based on the organ system:
1. Renal
What are the symptoms of SLE and what questions would you ask in history?
Describe this image.
malar rash indicative of SLE
Describe this image. What disease is this seen in?
livedo reticularis (APS)
What are the signs of SLE?
What antibody in SLE can cause neonatal lupus or congenital heart block?
Anti Ro
You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. urine dipstick
2. urine analysis
3. ECG
You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. FBC
You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. autoantibody screen
You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. U&E
You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. CXR
You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. kidney biopsy
What are the investigations needed to support your diagnosis of SLE.
What is the conservative management of SLE?
What is the acute pharmacological management of SLE?
How are the skin and joint symptoms of SLE managed?
How are the multi organ manifestations of SLE treated?
What is the chronic pharmacological management of SLE including escalations.
What malignancies typically complicate SLE?
What are the complications of SLE?
What is a major poor prognostic factor of SLE? What are some other poor prognostic factors?
Is CNS lupus a/w early or late mortality? What about ESKD/ infection?
In what condition is the following autoantibody most commonly detected:
1. anti ds-dna
SLE
In what condition is the following autoantibody most commonly detected:
1. anti smith
SLE
In what condition is the following autoantibody most commonly detected:
1. anti RO
Sjogren’s
In what condition is the following autoantibody most commonly detected:
1. anti la
Sjogren’s
In what condition is the following autoantibody most commonly detected:
1. anti RNP
MCTD
In what condition is the following autoantibody most commonly detected:
1. anti-Sm
SLE
In what condition is the following autoantibody most commonly detected:
1. anti Jo1
polymyositis
In what condition is the following autoantibody most commonly detected:
1. anti scl70
systemic sclerosis
