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Ch. 9 - Rheumatology > Systemic Lupus Erythematosus > Flashcards

Systemic Lupus Erythematosus Flashcards

1
Q
A
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2
Q

What are anti-nuclear antibodies? How are they detected and reported? What diseases is it associated with?

A
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3
Q

What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.

A
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4
Q

What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.

A
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5
Q

What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.

A
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6
Q

What is the most likely dx based on the ANA immunofluorescence?
ALSO describe the immunofluorescence shown.

A
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7
Q

How would you define SLE?

A

Multisystem inflammatory autoimmune disease characterised by autoantibody production of ANA+ve, Anti-DsDNA + C3C4, AntiRO, AntiSm(ith).

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8
Q

What antibodies in SLE are most associated with SLE?

A

AntiSM (most)
AntiDS DNA

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9
Q

What is the effect of AntiRo in an SLE patient when it crosses the placenta?

A
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10
Q

Which SLE antibody is also common in Sjogren’s?

A

AntiRO

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11
Q

How are Anti-DsDNA and C3C4 related in SLE?

A
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12
Q

What drugs can cause drug induced lupus? What Ab is present?

A
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13
Q

What is the gender distribution of SLE?

A
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14
Q

Describe the pathophysiology of SLE.

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15
Q

What are the systemic symptoms of SLE?

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16
Q

What organ systems are affected by SLE?

A

Skin and mucosa
joints
CNS
Cardio
Resp
Immune
Haematological (BM)
Renal

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17
Q

What are the manifestations of SLE based on the organ system:
1. Skin and mucosa

A
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18
Q

What are the manifestations of SLE based on the organ system:
1. Joint

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19
Q

What are the manifestations of SLE based on the organ system:
1. CNS

A
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20
Q

What are the manifestations of SLE based on the organ system:
1. Cardio

A
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21
Q

What are the manifestations of SLE based on the organ system:
1. Resp

A
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22
Q

What are the manifestations of SLE based on the organ system:
1. Immune

A
23
Q

What are the manifestations of SLE based on the organ system:
1. Haematology

A
24
Q

What are the manifestations of SLE based on the organ system:
1. Renal

A
25
Q

What are the symptoms of SLE and what questions would you ask in history?

A
26
Q

Describe this image.

A

malar rash indicative of SLE

27
Q

Describe this image. What disease is this seen in?

A

livedo reticularis (APS)

28
Q

What are the signs of SLE?

A
29
Q

What antibody in SLE can cause neonatal lupus or congenital heart block?

A

Anti Ro

30
Q

You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. urine dipstick
2. urine analysis
3. ECG

A
31
Q

You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. FBC

A
32
Q

You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. autoantibody screen

A
33
Q

You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. U&E

A
34
Q

You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. CXR

A
35
Q

You have been asked to investigate a patient with SLE. For each of the following investigations, state your expected findings.
1. kidney biopsy

A
36
Q

What are the investigations needed to support your diagnosis of SLE.

A
37
Q

What is the conservative management of SLE?

A
38
Q

What is the acute pharmacological management of SLE?

A
39
Q

How are the skin and joint symptoms of SLE managed?

A
40
Q

How are the multi organ manifestations of SLE treated?

A
41
Q

What is the chronic pharmacological management of SLE including escalations.

A
42
Q

What malignancies typically complicate SLE?

A
43
Q

What are the complications of SLE?

A
44
Q

What is a major poor prognostic factor of SLE? What are some other poor prognostic factors?

A
45
Q

Is CNS lupus a/w early or late mortality? What about ESKD/ infection?

A
46
Q

In what condition is the following autoantibody most commonly detected:
1. anti ds-dna

A

SLE

47
Q

In what condition is the following autoantibody most commonly detected:
1. anti smith

A

SLE

48
Q

In what condition is the following autoantibody most commonly detected:
1. anti RO

A

Sjogren’s

49
Q

In what condition is the following autoantibody most commonly detected:
1. anti la

A

Sjogren’s

50
Q

In what condition is the following autoantibody most commonly detected:
1. anti RNP

A

MCTD

51
Q

In what condition is the following autoantibody most commonly detected:
1. anti-Sm

A

SLE

52
Q

In what condition is the following autoantibody most commonly detected:
1. anti Jo1

A

polymyositis

53
Q

In what condition is the following autoantibody most commonly detected:
1. anti scl70

A

systemic sclerosis

Ch. 9 - Rheumatology (11 decks)

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