Sjogren's Syndrome Flashcards
Define Sjogren’s syndrome.
What is the gender distribution and age of onset of Sjogren’s?
What is the pathophysiology of Sjogren’s?
What drugs can cause sicca syndrome?
What are the 2 main symptoms of idiopathic Sicca syndrome?
What are the ddx for Sjogren’s?
What are the signs and symptoms of Sjogren’s and what symptoms must be ruled out?
What would you expect to find on FBC of Sjogren’s?
anaemia, leucopenia, lymphopenia, thrombocytopenia
What would you expect to find on autoantibody screen of Sjogren’s?
What would you expect to find on U+E of Sjogren’s?
What would you expect to find on serum protein sampling in Sjogren’s?
hyperglobulinemia, cryoglobulinemia in 20%
What would you expect to find on Schirmer Test in Sjogren’s? ALSO what is this test?
filter paper placed on lower eyelid (conjunctival sac) and pt asked to keep eyes closed for 5 min - <5mm in 5min - +ve
What would you expect to find on Lip biopsy in Sjogren’s?
Clusters of lymphocytes
What investigations would you order for Sjogren’s? What are your expected findings?
Outline the conservative management of Sjogren’s?
Outline the chronic management of dry eyes in Sjogren’s?
Outline the chronic management of dry mouth in Sjogren’s? What is a SE of the drug?
Outline the chronic management of dry skin in Sjogren’s?
Outline the chronic management of joint and skin manifestations in Sjogren’s?
Outline the chronic management of multisystem manifestations in Sjogren’s?
Outline the FULL management of Sjogren’s?
What cancers are a/w Sjogren’s? What other diseases is it a/w?
