Rheumatoid Arthritis Flashcards
A person with rheumatoid arthritis get a CXR after complaining of dyspnoea. What is the most likely cause?
Methotrexate-induced pneumonitis or fibrosis
Note that this can occur at any time during the course of treatment even after years. Also note that it is not dose-dependent so it can occur both at low and high doses
Define Rheumatoid arthritis.
What is the gender distribution of RA?
F:M 3:1
List the RFs for RA.
Describe the pathophysiology of RA.
Compare OA and RA in terms of:
1. onset
2. age
3. symmetry
4. morning stiffness
5. joints
5. localization
6. sparing
7. inflammatory markers
What are the joint symptoms of RA?
What are the extra articular features of RA?
You have been asked to do a hand exam on a RA patient. What are you looking for?
What would you expect to see on examination of the feet of an RA patient?
You have been asked to examine a patient with RA for extra articular manifestations. What are you looking for?
Label the image
Label the image
What are the diagnostic investigations for RA? What are your expected results?
Why do RA patients show anemic on FBC?
Why do RA patients get CKD?
What are your expected CXR findings in a RA patients?
What are your expected MRI findings in a RA patients?
Why is a DEXA performed for an RA patient?
What are the x ray findings of RA?
What are the supportive investigations for RA? What are your expected results?
Describe this image.
subchondral sclerosis
joint space narrowing
What are all your investigations for RA?
How would you grade the severity of RA? How often is it done?
Outline the conservative management of RA.
What is the max number of steroid injections can a patient with RA receive in 1 yr?
What is the acute management of RA?
Outline the chronic pharmacological management of RA.
DMARDS:
MTX
Leflunomide
Sulfasalazine
Biologics:
Anti-TNF
Anti-IL
B-cell
Jak
What is the surgical management of RA?
A 30 year old woman with a background of RA comes into the clinic for check up. She is currently on methotrexate. She explains that she wants to get pregnant and asks for conception advice. Would you consider changing her DMARD? If yes.. what would you next best option be?
Stop MTX, start sulphasalazine.
How would you monitor a patient on methotrexate?
What is the MOA, dosage, route of administration and SE of the following:
1. Methotrexate
What is the MOA and SEs of the following:
1. Methotrexate
How would you monitor a patient on biologics?
What is the pre-tx investigation for biologics?
List examples of the following:
Anti-TNF α
List examples of the following:
Anti-IL
List examples of the following:
Anti CD20
List examples of the following:
JAK inhibitor
What are the complications of RA?
What are the poor prognostic factors of RA?
