Systemic Effects of CVS Disease Flashcards
Define cardiac failure.
Failure of the heart to pump sufficient blood to satisfy metabolic demands, resulting in under-perfusion which causes fluid retention and increased blood volume.
Who is more likely to show symptoms of heart failure, an active person or a sedentary person who doesn’t exercise (assuming both do have cardiac failure) ? Explain why.
The active person is more likely to be symptomatic (because higher metabolic demands, more difficult for heart to pump sufficient blood to satisfy those).
Distinguish between acute, chronic and acute-on-chronic heart failures.
• Acute heart failure
– rapid onset of symptoms, often with definable cause e.g. myocardial infarction, ventricular septal defect
• Chronic heart failure
– slow onset of symptoms, associated with, for example, ischaemic or valvular heart disease. May be multiple causes.
• Acute-on-chronic heart failure
– chronic failure becomes decompensated by an acute event (e.g. chronic cardiac failure patients gets a further MI)
What is systolic cardiac failure ?
• Failure of the pump to move blood in systole (due to reduced ejection fraction and reduced ventricular contraction)
What are the causes of systolic cardiac failures ?
- Myocardial ischaemia
- Myocardial infarction
- Myocardial scarring
- Myocarditis
- Drugs eg alcohol, anti-cancer cytotoxics, cocaine
- Muscular disorders eg DMD
What are the effects of systolic cardiac failure ?
- Reduced cardiac output
- Feedback to atria and right side of heart (may start with L ventricular hypertrophy, but over time R ventricular hypertrophy due to probably backflow problem)
- Pulmonary oedema (due to increased pulmonary pressure) then
- Peripheal oedema (due to congestion of systemic capillaries)
Can systolic and diastolic cardiac failure coexist ?
Yes.
Is the fluid making up pulmonary and peripheral oedema in systolic cardiac failure exudate or transudate ? Why ?
The fluid making up pulmonary and peripheral oedema in systolic cardiac failure is transudate (if it were exudate, it would synonymous with inflammation, with protein leakage)
How do we treat systolic heart failure (what do we have to address) ?
Support
What is diastolic heart failure ?
Failure of ventricular wall to relax due to restrictive, stiff ventricle leading to reduced ventricular filling, reduced blood for systole and finally elevated end diastolic pressure.
What are the causes of diastolic heart failure ?
- Scarring (fibrotic heart) plus most causes of systolic
* Infiltrative disease eg amyloid
What are the effects of diastolic heart failure ?
- None
- Pulmonary and peripheral oedema •Response to exercise (intolerance)
- Tachycardia and pulmonary acute oedema
How do we treat diastolic heart failure (what do we have to address) ?
•Reduce AV conduction
What is another name for diastolic heart failure ?
Heart failure with preserved ejection fraction
Are the right ventricular failure’s effects primarily systemic or pulmonary ? the left ventricular failure’s effects ?
- Right: Primary effects systemic
* Left: Primary effects pulmonary
Identify the the causes of left and right ventricular failure.
• CHD
• HYPERTENSION
• CARDIOMYOPATHIES: Familial/genetic or non-familial/non-genetic (including acquired, e.g. Myocarditis) Hypertrophic (HCM), dilated (DCM), restrictive (RCM), arrhythmogenic right ventricular (ARVC), unclassified
• DRUGS: beta-Blockers (if reduce hypertension to slow HR, heart function decreases, i.e. can be promoting cardiac failure), calcium antagonists, antiarrhythmics, cytotoxic agents
• TOXINS: Alcohol, medication, cocaine, trace elements (mercury, cobalt, arsenic)
• ENDOCRINE: Diabetes mellitus, hypo/hyperthyroidism, Cushing syndrome, adrenal insufficiency, excessive growth hormone, phaeochromocytoma
• NUTRITION: Deficiency of thiamine, selenium, carnitine. Obesity, cachexia
• INFILTRATIVE Sarcoidosis, amyloidosis, haemochromatosis, connective tissue
disease
• OTHERS Chagas’ disease, HIV infection, peripartum cardiomyopathy, end- stage renal failure
Left ventricular failure is particularly resulting from hypertensive and ischaemic heart failure
Right ventricular failure is particularly
caused by:
- Left ventricular failure
-Intrinsic lung disease
-‘Cor pulmonale’ due to pulmonary hypertension
-Primary pulmonary hypertension