Systemic Disease Flashcards
What is the most likely way periodontitis influences systemic disease?
Triggering factors -> local reactions -> mediators (inflammatory cytokines) -> secondary systemic reaction
Acute phase reaction cascade
What are some important acute phase proteins?
- Complement components
- Protease inhibitors
- CRP
- Fibrinogen
- Plasminogen
What qualities define a risk factor?
- Consistency, strength, and specificity of association
- Time sequence
- Degree of exposure
- Biological plausibility
- Support from experimental evidence
T/F: There is good evidence and biological support for an association between periodontal disease and atherosclerotic vascular disease.
True
What are the major confounding factors associating periodontitis to AVD?
Smoking, age, diabetes, socioeconomic status
T/F: There is strong evidence that treatment of periodontitis will reduce the risk of AVD.
False
One of the most noticed mediators for AVD that is elevated in periodontitis is _______.
CRP
T/F: A causal relationship between PD and AVD has been shown.
False
T/F: Periodontal therapy significantly reduces overall rates of pre-term birth and low birth weight.
False
T/F: Although further study is needed, there is an emerging association between PD and bacterial pneumonia.
True
Aspirated oral bacteria
