Systemic Autoimmune Diseases--Nelson

Question 1

What does it mean to be immune priviledged?

Answer 1

hidden from immune system

(testes, eye, etc.)

Question 2

Two components of autimmune diseases

Answer 2

genetic suceptibility + exposure

Question 3

Untreated autimmune diseases become

Answer 3

progressive

waxing and waning but slowly progressive

Question 4

SLE pathology

Answer 4

type III hypersensitivity component

immune complexes–>binding to tissues–>lumpy deposition

type II hypersensitivity component

result of antibodies against blood components

Question 5

Antiphospholipid antibodies in SLE

Answer 5

prolonged PTT

but: hypercoagulable state

Question 6

Where does SLE normally manifest

Answer 6

kidneys: proteinuria, cellular casts, lupus nephitis

skin: malor rash, photosensitivity

joints: non-erosive small joint involvement

heme: cytopenias

Question 7

Antibodies against this in RA

Answer 7

citrullinated proteins/peptides

Question 8

Rheumatoid nodules

Answer 8

areas with central fibirinoid necorsis surrounded by a plisade of macrophages and scattered chronic inflammatory cells

Question 9

Sjogren syndrom pathology

Answer 9

autoimmune destruction of lacrimal and salivary glands

Question 10

SS-A and SS-B antibodies seen in which disease

Answer 10

Sjogren’s

Question 11

Sjogren’s has what antibodies?

Answer 11

SS-A and SS-B

Question 12

Sjogren maligancy risk

Answer 12

marginal zone lymphoma

Question 13

Antibodies in scleroderma

Answer 13

Scl-70 (DNA Topo-I)

Question 14

Scleroderma

Answer 14

chronic inflammaiton of small blood vessels + progressive interstitial and pervascular fibrosis of skin and other organs

Question 15

Diffuse scleroderm

Answer 15

widespread, rapid, early visceral involvement

Question 16

Limited scleroderma

Answer 16

only skin

Question 17

CREST syndrom

Answer 17

scleroderma

calcinosis, Raynaud’s, esphageal dysmotility, sclerodactylyly, telangetasia

Question 18

Anti-Jo1 antibodies

Answer 18

polymyositis