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IHO Wk 5 > Regulation of the Immune Response--Diebs > Flashcards

Regulation of the Immune Response--Diebs Flashcards

1
Q

What are the two types of DC with relation to regulating the immune response?

A

immunogenic: activating immune response

tolerogenic: leads to anergy

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2
Q

Immunogenic DC properties

A

good MHC and costimulatory molecule presentation

–> CD4+ T-cell activating

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3
Q

Tolerogenic DC properties

A

poor MHC and costimulatory molecule presentation

–> anergy of T-cell

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4
Q

4 Treg effector mechanisms

A

immunosuppressive cytokines

IL-2 consumption

cytolysis

modulation of DC maturation and function

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5
Q

Immunosuppressive cytokines secreted by Treg

A

IL-10, TGFβ, IL-35

–> cell cycle arrest

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6
Q

IL-2 consumption by Treg

A

CD25-mediated

–>steals IL-2 from other proliferating CD4+ T-cells

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7
Q

Cytolysis mediated by Treg

A

perforin: poke holes
granzymes: activate caspase cascade

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8
Q

Treg modulation of DC maturation and function

A

CTLA-4

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9
Q

IL-2 function

A

T-cell proliferation

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10
Q

IL-10 function

A

dampen immune response

anti-inflammatory

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11
Q

IL-12 function

A

activate Th1 T-cells

–> Th1 produce IFNγ and TNFα

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12
Q

IL-35 function

A

Treg proliferation

suppresses other CD4+ subsets

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13
Q

TGFβ function

A

suppresses CD4+ activity

(also needed to activate Th17?)

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14
Q

CCR7 function

A

matures DC

(C-C chemokine receptor)

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15
Q

CD25

A

IL-2 receptor

cell proliferation

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16
Q

What cell type produces IL-4?

17
Q

What cell type produces IL-5?

18
Q

What cell type produces IL-10?

19
Q

What cell type produces IL-13?

20
Q

What cell type produces IL-17?

21
Q

What cell type produces IL-35?

A

Treg

Treg proliferation

dampens other immne responses

22
Q

What cell type produces IFNγ?

23
Q

What cell type produces TNFα/β?

24
Q

Mechanisms of antibody-dependent B-cell suppression (2)

A
  • crosslinking/blocking receptor-epitope complex formation
  • antibody/epitope complex may activate inhibitor signal
25
Q

Antibody-dependent B-cell augmentation mechanism

A

immune complex formation

–> follicular DC may hold antigen in place

==> improved immune response

26
Q

IPEX

A

immune dysregulation, polyendocrinopathy, enteropathy, X-linked

27
Q

IPEX gene mutation

A

Foxp3

–> transcription factor in Treg cells

–> absence of Treg cells

–>autoimmunity

28
Q

Lab findings in IPEX

A

low Foxp3 + cells

eosinophilia

high IgE

29
Q

IPEX Tx

A

BM transplant

30
Q

APECED pathology

A

AIRE gene mutation

–> autoimmune regulator (usually in thymus)

–> autoantibodies produced

31
Q

APECED Tx

A

symptomatic

depending on manifestation

IHO Wk 5 (8 decks)

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