Syphilis Flashcards
definition of Syphilis
What does definition of Syphilis respond to?
Causative organism of Syphilis
Shape of Treponema pallidum
Motility of Treponema pallidum
Staining of Treponema pallidum
Culture of Treponema pallidum
Fragility of Treponema pallidum
Types of Treponemes
Why should examination for oral lesions in syphilis be avoided?
Pathogenesis of syphilis
How does Treponema palidum enter the body?
First lesion in syphilis after it enters the body
what happens after Treponema palidum enters the body through skin?
How does someone infected by Treponema palidum enter 3ry stage?
what happens at the end of latent phase of infection by Treponema palidum?
Is there long standing immunity to Treponema palidum?
Natural course of untreated syphilis
IP of syphilis
when soes chancre appear in syphilis?
Healing of chanvre of syphilis
when does secondry stage of syphilis occur?
Results of Serological tests in early latent syphilis
Histopathology of Syphilis
Endarteritis obliterans in syphilis
what doesEndarteritis obliterans in syphilis cause?
Perivascular infiltration in syphilis
Fibroblast activity in syphilis
Time of perivascular infeltration
Time of fibroblast activity
Introduction to Serological Tests of Syphilis
Types of Serological Tests of Syphilis
What do Non-treponemal or reagin tests (Non-specific) measure?
Types of Non-treponemal or reagin tests (Non-specific)
Examples of Flocculation or precipitation tests
Example of Complement fixation tests
when do Reagin tests become positive?
Results of VDRL in 2ry syphilis
Specificity of reagin tests for syphilis
Results of VDRL in 3ry syphilis
Follow up for syphilis using VDRL
Is Serological result for syphilis affected by effective therapy in early stages?
what do Treponemal tests (specific) measure?
Examples of Treponemal tests (specific)
Results of Treponemal tests (specific)
Value & Importance of serological tests of syphilis
Diagnosis of syphilis via serological tests of syphilis
Follow up for syphilis via serological tests of syphilis
what are Biological false positive (BFP) reactions for syphilis?
Definition of Acute BFP reactions for syphilis
Examples of Acute BFP reactions for syphilis
Def of Chronic BFP reactions for syphilis
Examples of Chronic BFP reactions for syphilis
Serologic test for syphilis in patients with HIV
Identification of Syphilis
DG examination in syphilis
Stained smeares in syphilis
EM of syphilis
Classification od syphilis
Stages of Acquired syphilis
Phases of Early stge of Acquired syphilis
Characters of Early stage of Acquired syphilis
Phases of Late stage of Acquired syphilis
Characters of Late stage of Acquired syphilis
Stages of Prenatal (congenital) syphilis
Main stages of Acquired Syphilis
MOI by Acquired Syphilis
Venereal route as a MOI by Acquired Syphilis
NON-Venereal route as a MOI by Acquired Syphilis
Can T.Pallidum penetrate skin, or mucus membrane?
IP of Acquired Syphilis
What does IP of Acquired Syphilis depend on?
Diagnostic Hallmark of Primary Syphilis
Definition of Chancre
Characters of Chancre
Duration of Chancre
Site of Chancre
Regional LNs In Chancre
How should Any painless genital ulcer be considered?
Special types of Chancres
Kissing chancres
Condom chancre
Concealed (Hidden) chancre
Phagedenic chancre
Diagnosis of chancre
Fate of primary syphilis
Investigations of primary syphilis
Identification of T. pallidum
Dark field microscopy in Diagnosis of Syphilis
Indirect fluorescent antibody test in diagnosis of syphilis
Serological tests in old chancre
DDx of Syphilis
Compare between Chancre & Chancroid
When does Secondary Syphilis appear?
Clinical Manifestations of Secondary Syphilis
Incidence of Skin rash (syphilides)
Characters of Skin rash (syphilides)
Number of eruptions of Skin rash (syphilides)
Types of skin rash in Skin rash (syphilides)
Course of Skin rash (syphilides)
Site of Condyloma lata (syphilitic moist papules)
Shape of lesions in Condyloma lata (syphilitic moist papules)
What is the most infectious lesion of 2ry syphilis?
Site of Mucous patches of syphilis
DDx of Condyloma lata (syphilitic moist papules)
Shape of Mucous patches of syphilis
what do Mucous patches of syphilis in the urethra cause?
DDx of secondary syphilis
LNs affection in sypjilis (2ry syphilis)
Other feature sof 2ry syphilis
Fate of 2ry syphilis
Types of Relapse in Relapsing Syphilis
Def of Relapsing Syphilis
Time of Relapsing Syphilis
Types of Relapsing Syphilis
what is the most common type of Relapsing Syphilis?
Chancre redux
Serological relapse
Other types of relapse
Time of Latent Syphilis
Diagnosis of Latent Syphilis
Clinical manifestations of Latent Syphilis
Latent syphilis is divided into ……
Characters of Early latent syphilis
Characters of Late latent syphilis
Duration of Late (Tertiary) Syphilis
Tertiary syphilis includes ….
Quaternary syphilis encompasses …..
Time of Benign Tertiary Syphilis
Characteristic lesion of Benign Tertiary Syphilis
what lesions does Benign Tertiary Syphilis include?
Classiification of gumma
Gumma of skin
Gummata of mucus membranes
Gummata of internal organs
Gummata of Liver
Gummata of stomach
Gummata of testicles
Paroxysmal cold haemoglobinuria (PCH)
Gummata of bones
Gummata of joints
Diagnosis of syphilitic gumma
Incidence of Neurosyphilis
Clinical Manifestations of Neurosyphilis
Why diagnosis of latent syphilis cannot be made unless asymptomatic neurosyphilis is excluded by a negative cerebrospinal fluid examination?
Features of Neurosyphilis
Prognosis of Neurosyphilis
Clinical manifestations of Cardiovascular Syphilis
Incidence of Cardiovascular Syphilis
Dx of Cardiovascular Syphilis
Prognosis of Cardiovascular Syphilis
Prevention of Prenatal (Congenital) Syphilis
Clinical Manifesttaions of Prenatal (Congenital) Syphilis
Def of Prenatal (Congenital) Syphilis
Characters of Early prenatal syphilis
Time of Early prenatal syphilis
Lesions in Early prenatal syphilis
General features in Early prenatal syphilis
Skin lesions in Early prenatal syphilis
Mucus membrane lesions in Early prenatal syphilis
Condyloma lata in Early prenatal syphilis
Dx of Early prenatal syphilis
Characters of Late prenatal syphilis
Time of Late prenatal syphilis
Types of Late prenatal syphilis
Characters of Late latent (asymptomatic) congenital syphilis
What is the most common character of Late symptomatic congenital syphilis?
Caracters of Late symptomatic congenital syphilis
Neurosyphilis in Late symptomatic congenital syphilis
Skin & MM Lesions in Late symptomatic congenital syphilis
Bone involvment on Late symptomatic congenital syphilis
Dx of Late symptomatic congenital syphilis
Def of Stigmata of prenatal syphilis
Types of Stigmata of prenatal syphilis
CP of Stigmata of early lesions
CP of Stigmata of late lesions
what is Hutchinson’s triad?
Dx of prenatal Congenital syphilis
Intro to Managment of Syphilis
✨……….✨is the drug of choice in all stages of the disease
Penicillin treatment regimens for acquired syphilis
Alt. TTT of Early acquired syphilis (primary, secondary, and early latent)
Alternative treatment Late latent and unknown duration, cardiovascular and gummatous syphilis; retreatment of primary, secondary or latent syphilis after failed initial treatment
What does Treatment regimens for congenital syphilis depend on?
TTT of Congenital Syphilis in cases of Normal CSF
TTT of Congenital Syphilis in cases of abnormal CSF
TTT of Congenital syphilis in children over the age of 15
Def of Jarisch-Herxheimer reaction
What are treatment reactions in syphilis?
Def of Therapeutic paradox
Duration of Jarisch-Herxheimer reaction
Mechanism of Jarisch-Herxheimer reaction
Managment of Jarisch-Herxheimer reaction
Types of Penicillin reactions
Def of Procaine reaction
Def of Vasovagal attack (faint)
