Synthesis of substituted aromatic compounds Flashcards
1
Q
Starting with a grignard reagent (PhMgBr) what reagents are needed to form a ketone?
A
1) R-C—N
2) H2O/H+
2
Q
Starting with a grind reagent (PhMgBr) what reagents are needed to form a aldehyde?
A
1) HC(OEt)3
2)H3O+
3
Q
Starting with a grind reagent (PhMgBr) what reagents are needed to form a benzyl alcohol (Ph-CH2OH-R)?
A
1) RCHO
2) H+
4
Q
Starting with a grind reagent (PhMgBr) what reagents are needed to form a benzoic acid?
A
1) CO2
2) H+
5
Q
What are the reagents for the Williamson ether synthesis?
A
K2CO3, Me2CO, R-I
6
Q
What are the reagents used for directed ortho-metallation?
A
n-BuLi and TMEDA
Topic 5 Card 2
7
Q
What are the reagents for the Claisen rearrangement?
A
1) K2CO3, Me2CO and CH2=CH-CH2-Br
2) Heat
See topic 5 card 3
