Alkene synthesis

Question 1

What are the reagents/requirements for an E2 Elimination?

Under what circumstances would an E1 elimination be preferable?

Answer 1

Base and a good leaving group

If the leaving group is a poor one then elimination via E1

Question 2

What are the reagents for the Wittig reaction?

Answer 2

1) PPh3
2) NaNH2 (or NaOEt)
3) Ketone

Question 3

What are the reagents for the Wittig-Homer (Abuzov) reaction?

Answer 3

R-X, (EtO)3P, heat

Question 4

What catalyst is used in olefin metathesis reactions?

Answer 4

Grubbs catalyst

See card 4 for structure

Question 5

What are the reagents used for Peterson olefination?

What kind of reaction is Peterson olefination?

Answer 5

Me3Si-CH3-M, Ketone
where M = Li/Mg
This is and alpha-silyl carbanion mediated olifination

Question 6

What are the reagents used for Julia olefination?

What kind of reaction is Julia olefination?

Answer 6

1) PhSO2Et, n-BuLi
2) Ac2O
3) Na/Hg MeOH