Electrophilic aromatic substitution Flashcards
1
Q
Electron donating groups direct?
A
Ortho, Para directing
1
Q
What are the reagents for the deuteration of phenol?
A
KOD, D2O
OR
DCl, D2O
2
Q
Electron withdrawing groups direct?
A
Meta directing
3
Q
What are the reagents for nitration?
A
C. H2SO4, HNO3
4
Q
What are the reagents for sulfonation?
A
C. H2SO4
5
Q
What are the reagents for Friedel-Crafts alkylation?
A
R-Cl, AlCl3
6
Q
What are the reagents for Friedel-Crafts acylation?
A
ROCl, AlCl3
7
Q
What are the reagents for Anhydride acylation?
A
Cyclic anhydride, AlCl3
see topic 3 card 4
8
Q
What are the reagents for the halogenation of phenol?
What positions get substituted?
A
3X2, EtOH, H2O
OH group of phenol is electron donating and so is Ortho, Para directing
