Synthesis And Metbolism

Question 1

Catacholamine’s

Answer 1

Tyrosine — L-Dopa — Dopamine— norepinephrin—Epinephrin

Question 2

How does Tyrosin become L-Dopa

Answer 2

TH- tyrosin hydroxylaze

Question 3

L-Dopa to Dopamine

Answer 3

LAAD

L-AROMATIC AMINO ACID DECARBOXYLASE DOPAMINE

Question 4

Dopamine to Norepinephrine

Answer 4

DOPAMINE b-HYDROXYLASE

Question 5

Norepinephrine to Epinephrine

Answer 5

PHENYLETHANOLAMINE N-METHYL TRANSFERASE

PNMT

Question 6

Dopamine metabolites

Answer 6

DOPAC (3,4-dihydroxyphenylacetic acid)
HVA (homovanilic acid)
3-MT (3-methoxytyramine)

Question 7

Dopamine metabolism enzymes

Answer 7

MAO
(monoamine oxidase) 
COMT
(catechol O-methyl transferase) 
ADH
(aldehyde dehydrogenase)

Question 8

DOPAMINE to DOPAC

Answer 8

MAO & ADH

Question 9

DOPAN to HVA

Answer 9

COMT

Question 10

DOPAMINE to 3-MT

Answer 10

Comt

Question 11

3-MT to HVA

Answer 11

MOA & ADH

Question 12

NOREPINEPHRINE METABOLITES

Answer 12

VMA (vanillylmandelic acid)

MHPG (3-Methoxy-4-hydroxyphenylglycol)

Question 13

NorEpinephrine to VMA

Answer 13

MOA & ADH & COMT

Question 14

NorEpinephrine to MHPG

Answer 14

AR = aldehyde reductase

MOA & AR & COMT

Question 15

Seratonin synthesis

Answer 15

TRYPTOPHAN to 5-HYDROXY TRYPTOPHAN (5-HTP) to SEROTONIN (5-HT)

Question 16

TRYPTOPHAN To 5-HYDROXY TRYPTOPHAN (5-HTP)

Answer 16

TRYPTOPHAN HYDROXYLASE

Enzyme

Question 17

5-HYDROXY TRYPTOPHAN (5-HTP) to SEROTONIN (5-HT)

Answer 17

L-AROMATIC AMINO ACID DECARBOXYLASE

Question 18

5-HT METABOLITE

Answer 18

5-HIAA (5-hydroxyindoleacetic acid)

Question 19

5-HT to 5-HIAA

Answer 19

MOA & ADH

Question 20

AcH synthesis

Answer 20

Choline and AcytlecoA (acytl group) are precursors that are joined together by CAT (choline acetyltransferase)

Question 21

Metabolism of AcH

Answer 21

One enzyme involved acytlcholine esterase

And give choline and acetate

Question 22

Metabolism of AN

Answer 22

FAAH

Question 23

Peptides synthesis (opiates)

Answer 23

precursor peptides (e.g. proopiomelanocortin (POMC), proenkephalin, prodynorphin)
Longer sequence and then they are clipped off
Long is POMC and has sequence of others