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Neuropsychopharmacology > Drugs > Flashcards

Drugs Flashcards

1
Q

Bromocriptine

A

Full agonist
D2 receptors
Antiparkinsonian

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2
Q

^9-THC

A

CB1 receptor

Full agonist

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3
Q

Morphine

A

Mue opiate receptor

Full agonist

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4
Q

Nicotine

A

Nicotinic AcH receptors
full agonist
Muscle contraction or twitching

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5
Q

Verenicline(chantix)

A

Causes smoking to have less effect acts on a nicotinic AcH receptor
Partial agonist

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6
Q

Haloperidol

A

D2 receptor
Competitive antagonist
Antipsychotic
Gi

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7
Q

Clozapine

A

Dopamine receptors
Competitive antagonist
Atypical antipsychotic

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8
Q

Reserpine

A

blocks DA storage and depletes DA

decreases 3-MT, but increases DOPAC & HVA

(VMAT-1&2)

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9
Q

tropolone

A

COMT inhibitor

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10
Q

phenelzine (Nardil)

A

MAO inhibitors
non-specific
Antidepressents

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11
Q

moclobemide

A

MAO-A

NE is a substrate for MAO-A

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12
Q

deprenyl

A

MAO-B (at low doses, tends to affect DA more; used as an antiparkinsonian drug)

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13
Q

Catacholamine RELEASING AGENTS (Calcium independent)

A

=d-amphetamine (Dexedrine)
=l-amphetamine (Benzedrine)
=methamphetamine (Methedrine, “meth”; “crank”); stimulate release of monoamines, act as major stimulants, used to treat ADHD, common recreational drug

Methylphenidate (Ritalin): stimulates catecholamine release, acts as major stimulant, used to treat ADHD

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14
Q

ropinirole

A

D2 agonist

Gi

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15
Q

Catacholamine UPTAKE INHIBITORS - blocking transporter levels of transmission is high (more transmitter in the synapse)

A 
Amphetamine
 Cocaine 
Methylphenidate (Ritalin) 
GBR 12909 (DA) 
Bupropion (Welbutrin, Zyban) (DA/NE) 
Desipramine (NE) anti depressent
DAT is dopamine transporter 
Sert for seratonin 
Nat norepinephrin
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16
Q

PCPA

A

inhibits TrypH, blocks 5-HT synthesis

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17
Q

Tryptophan

A

Precursor

Deprevation reduces 5-HT

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18
Q

Tetrabenazine

A

(VMAT-2; less effect on 5-HT)
Storage of monoamine depletion and blocking

Block vesicular storage of monoamines (VMAT inhibitors)

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19
Q

p-chloroamphetamine;

A

5-HT RELEASE
potent at release of 5HT
higher doses of other amphetamines also release 5-HT

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20
Q

Mianserin

A

5-HT2 family antagonist

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21
Q

Pimavanserin

A

5-HT2A inverse agonist

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22
Q

clozapine, risperidol

A

Atypical Antipsychotics: clozapine, risperidol and related drugs are antagonists or inverse agonists of 2A and/or 2C receptor subtypes; many hallucinogens (e.g. LSD) also bind to 2A
Seratonin

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23
Q

Fluoxetine (prozac)

A

5_HT uptake

Selective in terms to DA and Epi and Norepi

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24
Q

Cocaine

A

Inhibit CA uptake
Uptake of seratonin
Non selective

25
Amphetamine
Higher doses affect uptake of seratonin
26
AcH esterase inhibitors ( blocking enzymatic enzymes) elevating Ach levels aka anticholinesterases
Physostigmine Tacrine (alzaheimrs ) Galantamine (alzheimers) DFP (organophosphate) irreversable inhibitors. Toxicity in farmers insecticides Sarin nerve gases irreversable binds covalntly
27
Hemicholinium-3
Block choline transporter | Less moves into the neuron and this reduces the synthesis of Ach
28
Scopolamine
Muscurinic antagonist antiparkinsonian, hallucinogenic (high doses) Autonomicsystem produce dry mouth and constipation, and dilate pupils. Drugs that block muscarinic receptors
29
Atropine
Muscurinic Antagonist antiparkinsonian, hallucinogenic (high doses) Drugs that block muscarinic receptors can produce dry mouth and constipation, and dilate pupils.
30
Muscurine
Muscurinic agonist
31
Pilocarpine
Muscurininc agonist
32
Mecamylamine
Nicotinic antagonist
33
Curare
Nicotinic antagonist used for research; can be lethal, stops the action of the diaphragm muscle; was used in blow darts and arrows in South America
34
Olanzopine
Block muscurinic receptors
35
MK 801 (dizocilpine)
noncompetitive NMDA antagonist, neuroprotective
36
PCP (phencyclidine) and ketamine
un-competitive NMDA antagonists.
37
Propranolol (Inderal)
b adrenergic competitive antagonists | used to treat high blood pressure
38
strychnine
Competitive antagonist in glycin | Rat poisin
39
physostigmine, tacrine, galantamine
tacrine & galantamine used to treat Alzheimer’s disease reversible anticholinesterases Affect the metabolism of Ach
40
nsecticides such as DFP, and the nerve gas Sarin
irreversible anticholinesterases
41
Bitopertin
GLYT-1 inhibitor, was evaluated as an adjunct treatment for schizophrenia
42
Rapastinel
GLY is a “co-agonist” on the NMDA receptor is a partial agonist of this site
43
istradefylline and preladenant
A2A antagonists such as istradefylline and preladenant have been evaluated in clinical trials as antiparkinsonian drugs; istradefylline is approved for use in Japan, recently approved in US
44
Caffeine and other methylxanthines
are non-selective adenosine antagonists.
45
THC, CP55940
CB1 Agonists: CP is much more potent Thc could be an anelgesic
46
AM4113; | rimonabant
CB1 Antagonists/inverse agonists | Rimonabat was studied as a food suppressent
47
Codeine
agonists of opiote receptors
48
heroin
semi-synthetic drug
49
``` Propoxyphene (Darvon) Meperidine (Demerol) Fentanyl (Sublimaze) mixed with heroin due to high potency and affinity Knee receptors Oxycodone (OxyContin) ```
``` Synthetic opiates (“opioids”): Anesthesia and surgery uses ```
50
Naloxone ( receptor)
Opiate receptor antagonist
51
Peptides
Oxytocin Vasopressin Cholecystokinin (CCK) Neuropeptide Y | Tachykinins (neurokinins) Substance P Kassinin Neurokinin A Eledoisin
52
methamphetamine
It not only blocks DAT, it is a substrate, transported into the terminal • Once inside the terminal, it stimulates release of DA • Inside the terminal, it also blocks VMAT-2; it also is a substrate, transported into the vesicles • It also inhibits MAO
53
FG7142
(benzodiazepine site) has effects opposite to benzodiazepines; can be described as a negative allosteric modulator
54
Pimavanserin:
5-HT2A inverse agonist; | used to treat hallucinations in Parkinson’s disease patients
55
neostigmine,
AChesterase inhibitor, used to treat neuromuscular dysfunction
56
stimulants, cold medicines/diet pills (ephedrine, phenylpropanolamine) that act on NE
These drugs can increase heart rate & blood pressure, and produce other signs of sympathetic activation
57
anticholinesterases, muscarinic agonists
Drugs that Stimulate ACh transmission: stimulate parasympathetic activity Can cause SLUD!!! Salivation Lacrimation Urination Defecation YUK!!!!!!!!!!!!!
58
tropicamide,
Antagonist of muscurinic can produce dry mouth and constipation, and dilate pupils. Drugs that block muscarinic receptors Dialating pupils for opthamologist

Neuropsychopharmacology (4 decks)

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