Synaptic Transmitters

Question 1

Lack of GABA inhibition is associated with

Answer 1

Epileptic seizures, Huntington’s disease

Question 2

Which biogenic amine is found in the ventral tegmenal area (VTA) of the midbrain?

Answer 2

Dopamine

Question 3

D1-D2 complex releases

Answer 3

Ca2+

Question 4

D1-like family:D1 and D5 receptors increase

Answer 4

the intracellular concentration of the secondary messenger cyclic adenosine monophosphate (cAMP)

coupled to protein Gas

Question 5

D2-like family: D2, D3, and D4 receptors inhibit

Answer 5

the formaiton of the cAMP by inhibiting the enzyme adenylate cyclase (coupled to G protein Gai)

Question 6

Which pathology is caused by degeneration of dopaminergic substantia nigra?

Answer 6

Parkinson’s disease

Question 7

Which disease is attributed to the lack of GABA dependent inhibition of neural pathways

Answer 7

Huntington’s disease

Question 8

Which neurotransmitter does cocaine block?

Answer 8

Cocaine blocks dopamine– acts as a serotonine-norepinephrine-doamine blocker

Question 9

The mesolimbic pathway is one of the _____ pathways in the blood. It has to do with ______

Answer 9

dopaminergic; addiction

Question 10

Which amine has normal fucnctions that involve mood, sleep, and cognition

Answer 10

5-HT (serotonin)

Question 11

Cocaine reuptakes:

Answer 11

serotonin, norepinephrine, dopamine