Collagen and ECM Flashcards

1
Q

What cleaves all proteins found in the ECM (including collagen and laminin)?

A
Matrix metalloproteinases
-expression of these enzymes allows cell migration and tissue remodeling during growth and differentiation
-destruction of the ECM by MMPs releases growth factors that may be bound to hte ECM- allows growth factors to bind to cell surface receptors to initiate growth of tissues
-Cancer cells that metastasize require extensive ECM remodeling and usually use MMP activity to spread throughout th ebody
MMPs are regulated by a class of inhibitors known as TIMPs-tissue inhibitors of metalloproteinases
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2
Q

Adhesive glycoproteins

A

Involved in

  • Wound healing
  • Cell attachment
  • Cell migration
  • Cell spreading
  • Chemotaxis
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3
Q

Core protein and GAGS on proteoglycan

A
Protein core
Xylose
Galactose
N-acetylgalactosamine
Glucoronic acid
Sulfate
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4
Q

Glucuronic acid+N-acetyl-glucosamine

A

Hyaluronate

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5
Q

Hyaluronate

A

Glucuronic acid+N-acetyl-glucosamine

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6
Q

Glucoronic acid + N-acetyl-galactosamine

A

Dermatan sulfate

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7
Q

Dermatan sulfate

A

Glucoronic acid + N-acetyl-galactosamine

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8
Q

Iduronic acid + Glucosamine

A

Heparin

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9
Q

Heparin

A

Iduronic acid + Glucosamine

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10
Q

Chondroitin 6-sulfate

A

Glucoronic acid + N-acetyl-galactosamine

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11
Q

Glucoronic acid + N-acetyl-galactosamine

A

Chondroitin 6-sulfate

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12
Q

Keratan sulfate

A

Galactose + N-acetyl-glucosamine

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13
Q

Galactose + N-acetyl-glucosamine

A

Keratan sulfate

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