Collagen and ECM Flashcards
1
Q
What cleaves all proteins found in the ECM (including collagen and laminin)?
A
Matrix metalloproteinases -expression of these enzymes allows cell migration and tissue remodeling during growth and differentiation -destruction of the ECM by MMPs releases growth factors that may be bound to hte ECM- allows growth factors to bind to cell surface receptors to initiate growth of tissues -Cancer cells that metastasize require extensive ECM remodeling and usually use MMP activity to spread throughout th ebody MMPs are regulated by a class of inhibitors known as TIMPs-tissue inhibitors of metalloproteinases
2
Q
Adhesive glycoproteins
A
Involved in
- Wound healing
- Cell attachment
- Cell migration
- Cell spreading
- Chemotaxis
3
Q
Core protein and GAGS on proteoglycan
A
Protein core Xylose Galactose N-acetylgalactosamine Glucoronic acid Sulfate
4
Q
Glucuronic acid+N-acetyl-glucosamine
A
Hyaluronate
5
Q
Hyaluronate
A
Glucuronic acid+N-acetyl-glucosamine
6
Q
Glucoronic acid + N-acetyl-galactosamine
A
Dermatan sulfate
7
Q
Dermatan sulfate
A
Glucoronic acid + N-acetyl-galactosamine
8
Q
Iduronic acid + Glucosamine
A
Heparin
9
Q
Heparin
A
Iduronic acid + Glucosamine
10
Q
Chondroitin 6-sulfate
A
Glucoronic acid + N-acetyl-galactosamine
11
Q
Glucoronic acid + N-acetyl-galactosamine
A
Chondroitin 6-sulfate
12
Q
Keratan sulfate
A
Galactose + N-acetyl-glucosamine
13
Q
Galactose + N-acetyl-glucosamine
A
Keratan sulfate
