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Exam 2 Information > Connective Tissue Fibers > Flashcards

Connective Tissue Fibers Flashcards

1
Q

Function of connective tissue

A

-Maintains form and structures

Fills spaces

Supports soft tissue

Stores fat

mechanical role

Defense- phagocytic cells and immune cells

Forms physical barriers

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2
Q

How is a collagen molecule formed?

  1. Peptide coiling into a triple helix (intracellular)

Extracellular cleavage of registration peptides

Following action of lysyl oxidase

Grouping of fibers

A

Extracellular cleaveage of registration peptides

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3
Q

Elastic fiber

A

Composed of microfibrils and elastins

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4
Q

What does fibrilin form

A

Microfibrils- made of the protein fibrilin

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5
Q

Elastins

A

contains 2 unique amino acids, desmosine and isodesmosine

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6
Q

What are desmosines and isodesmosines made of?

A

4 lysine residues

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7
Q

Characteristics of elastic

A

Stretches easily, returns to shape

Resistant to boiling, acids, and protease digestion

Fibers branch

Forms cloth-like structure in walls of some blood vessels

Special stain required (ex. Verhoff’s or Weigerts)- normally stains dark pink or black

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8
Q

Location of elastin

A 
Loose CT
Elastic CT
Elastic cartilage
Elastic arteries
Ligaments 
Dermis
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9
Q

Does collagen branch?

A

NO

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10
Q

If there was a defect in the protein fibrillin, which component of the elastic fiber would be affected the most?

  1. Elastin core
  2. Microfibrils
  3. Fibril branching
  4. Fiber staining with Weigerts
A

Microfibrils

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11
Q

Reticular fibers-composition

A

Most type 3 collagen that is heavily glycosylated

Other minor components: glycoproteins, other colllagens, preoteoglycans

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12
Q

Cells rich in reticular

A

Fibroblasts

Reticular cells (Hematopoietic)

Schwann cells

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13
Q

Reticualr fibers- characteristics

A

Thin fibers

Fibers branch- due to other components and interactions

Form networks-very flexible

Argyrophilic (siler loving)

PAS-positive-high glycoproteins

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14
Q

Organelles rich in reticular fibers

A

Spleen
Adipose
Liver
Endocrine glands
Lymph Nodes

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15
Q

Which connective tissue is argyrophilic?

A

Recicular fibers

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16
Q

Do all connective tissue have ground substance/

A

YES

17
Q

Function of ground substance/

A

Fills spaces
Lubricant
Barrier-very viscous
Binds cells to fibers

18
Q

Composition of ground substance

A

glycosaminoglycans
Proteoglycans
Proteoglycan aggregates
glycoproteins

19
Q

Characteristics of ground substance?

A

Colorless, transparents

Hydrated

Gel-like consistency

20
Q

Glycosaminoglycans

A

Ground substance

Repeating disaccharides

21
Q

Characteristics of GAG

A 
Linear polysaccharides
most are sulfated- what binds the water. Makes them hydrated
Composition of sugars
Linkage between sugars
Location of sulfate groups
22
Q

Hyaluronic acid is a type of

A

A type of GAG

23
Q

Proteoglycan composition

A

Linear protein, and attached are GAGS

24
Q

Which of hte following provides the best description of proteoglycans

Chains of repeating dissachharides
GAGS attached to a core protein
Branched carbohydrate attached to a protein
Link proteins attaching

A

GAGS attached to a core protein

25
Q

A laboratory technician has isolated and purified a component o fth eextracellular matrix. Upon further investigation, it is shown that th molecules contain equal amoungs of sugar galactosamine and iduronic acid and a lesser amount of protein. Which of the following would be the best way to classify this molecule?

A. Glycosaminoglycan
B. P

A

Proteoglycan

26
Q

A laboratory technician has isolated and purifid another component of hte extracellular matrix. This component has a large globular protein and branched chains of carbohydrates

A

glycoprotein

27
Q

What are the 3 classificatoins of components that all connective tissues are made of?

A

Cells, fibers, ground substnace

28
Q

A graduate student is trying to identify a structure seen in a histology slide. The sturcture requires a special stain. Biochemical analysis showed that it contains desmosine and

A

Elastic fibers

29
Q

Which type of connective tissue would you most likely find immediately beneath epithelium?

A

Loose CT

30
Q

Elastic cells

A

Fibroblast
Smooth muscle cells
Chrondrocytes

31
Q

Location of elastic connective tissue

A 
Loose CT
Elastic CT
Elastic cartilage
Elastic arteies
Ligaments
Dermis
32
Q

Reticular formation-cells

A

Fibroblasts
Reticular cells
Schwann cells

33
Q

Location of reticular fibers

A 
Spleen
Lymph nodes
Liver
Endocrine glands
Adipose
34
Q

Fixed cells of specialized CT

A

Adipocytes
Chondrocytes
Osteocytes
Reticular cells

35
Q

Compound gland, parenchyma

A

The gland and duct portion of the compound gland

36
Q

Compound gland, stroma

A

The connective tissue component of the compound gland

Exam 2 Information (8 decks)

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