Synaptic transmission drugs

Question 1

Metyrosine (mechanism of action)

Answer 1

Competitive inhibition of tyrosine hydroxylase

Question 2

Reserpine (mechanism of action)

Answer 2

Inhibits VMAT uptake of monoamines

Question 3

Bretylium (mechanism of action)

Answer 3

Inhibit action potential generation and calcium dependent synaptic vesicle fusion

Question 4

Cocaine (mechanism of action)

Answer 4

Blocks monoamine reuptake

Question 5

Amphetamine or ephedrine (mechanism of action)

Answer 5

Reverse monoamine re-uptake transporters

Question 6

Naloxone, Naltrexone (mechanism of action)

Answer 6

Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs (mechanism of action)

Answer 7

Selective inhibition of serotonin re-uptake transporter

Question 8

ACE inhibitors, e.g. lisinopril (mechanism of action)

Answer 8

Inhibits peptide cleavage of Angiotensin I to Angiotensin II

Question 9

Phenylephrine (mechanism of action)

Answer 9

Direct agonist of adrenergic receptor

Question 10

MAO inhibitors (mechanism of action)

Answer 10

Blockade of cytoplasmic metabolism of monoamines

Question 11

L-DOPA (mechanism of action)

Answer 11

Precursor of dopamine, stimulates dopamine production

Question 12

Carbidopa

Answer 12

Blocks L-DOPA conversion to dopamine, not crossing the BBB. Protects peripheral adrenergic neurons from producing too much dopamine and NE

Question 13

Tyramine

Answer 13

Competes with NE for transport into synaptic vesicle