Opioid Analgesics Flashcards
Location of delta receptors
Brain
- Pontine nuclei
- Amygdala
- Olfactory bulbs
- Deep cortex
Location of kappa receptors
Brain
- Hypothalamus
- Periaqueductal gray
- Claustrum
Spinal cord
- Substantia gelatinosa
Location of mu receptors
Brain
- Cortex (lamina III-IV)
- Thalamus
- Striosomes
- Periaqueductal duct
Spinal cord
- Substantia gelatinosa intestinal tract
Location of nociceptin receptor
Brain
- Cortex
- Amygdala
- Hippocampus
- Septal nuclei
- Habernula
- Hypothalamus
Spinal cord
Opioid receptors found at pre-synaptic membrane
Kappa, delta, and mu
Opioid eceptors found at post-synaptic membrane
Mu ONLY
Pre-synaptic opioid receptors action on channels
Decrease Ca2+ channel influx, increase K+ efflux. Decrease in transmitter release (hyperpolarization)
Post-synaptic opioid receptor actions on channels
Increase K+ efflux
IPSP (inhibitory post synaptic potential)
Effects of delta opioid receptors
Analgesia
Antidepressant effects
Physical dependence
Effects of kappa opioid receptors
Spinal analgesia Sedation Miosis Inhibition of ADH release Dysphoria
Effects of mu1 opioid receptors
Supraspinal analgesia
Physical dependence
Effects of mu2 opioid receptors
Respiratory depression Miosis Euphoria Reduced GI motility Physical dependence
Effects of mu3 opioid receptors
?????
Effects of nociceptin opioid receptors
Anxiety
Depression
Appetite
