Serotonin and Dopamine Flashcards by P K | Brainscape

Q

5-HTP (mechanism of action)

A

5-HT (serotonin) precursor

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Q

5-HTP (indication)

A

Depression

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Q

Buspirone (mechanism of action)

A

HT1A partial agonist

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Q

Buspirone (indication)

A

anxiety/depression

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Q

Sumatriptan (mechanism of action)

A

HT1D agonist

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Q

Sumatriptan (indication)

A

migraine

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Q

Sumatriptan (side effect)

A

coronary vasoconstriction

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Q

Buspirone (side effect)

A

early increase in anxiety

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Q

Risperidone (mechanism of action)

A

HT2A/2C antagonist

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Q

Risperidone (indication)

A

depression/psychosis

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Q

Risperidone (side effect)

A

weight gain; akathesia***

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Q

Odansetron (mechanism of action)

A

HT3

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Q

Odansetron (indication)

A

chemo-induced emesis

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Q

Fluoxetine (mechanism of action)

A

SSRI

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Q

Fluoxetine (indication)

A

depression; OCD; anxiety; panic disorder; PTSD; social phobia

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Q

Fluoxetine (side effect)

A

Sexual dysfunction; insomnia

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Q

Sertraline (mechanism of action)

A

SSRI

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Q

Sertraline (indication)

A

anxiety; social phobia; OCD; PTSD; depression; panic disorder

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Q

Sertraline (side effect)

A

Sexual dysfunction; insomnia

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Q

L-DOPA (mechanism of action)

A

dopamine precursor

Q

L-DOPA (indication)

A

Parkinson’s disease

Q

L-DOPA (side effect)

A

arrhythmia; dyskinesia

Q

bromocriptine (mechanism of action)

A

D2 agonist

Q

bromocriptine (indication)

A

Parkinson’s disease

Q

carbidopa (mechanism of action)

A

aromatic acid decarboxylase inhibitor

Q

carbidopa (indication)

A

Parkinson’s disease

Q

carbidopa (side effects)

A

same as L-DOPA: arrhythmias and/or dyskinesia

Q

selegiline (mechanism of action)

A

MAO-B inhibitor

Q

selegiline (indication)

A

Parkinson’s disease

Q

talcapone (mechanism of action)

A

COMT inhibitor

Q

talcapone (indication)

A

Parkinson’s disease

Q

Role of COMT

A

degrades dopamine, other catecholamines (epi, NE)

Q

methylphenidate (brand name)

A

Ritalin

Q

methylphenidate (mechanism of action)

A

dopamine uptake inhibitor

Q

methylphenidate (indication)

A

ADHD

Q

methylphenidate (side effect)

A

tachycardia

Q

metaclopramide (mechanism of action)

A

D2 antagonist

Q

metaclopramide (indication)

A

nausea

Q

metaclopramide (side effect)

A

akathasia

Q

haloperidol (mechanism of action)

A

D2 antagonist

Q

haloperidol (indication)

A

psychosis

Q

haloperidol (side effect)

A

extra-pyramidal motor disturbances

Q

dopamine (mechanism of action)

A

dopamine and adrenergic receptor agonist

Q

dopamine (indication)

A

shock; cardiac decompensation

Q

dopamine (side effect)

A

hypotension (low dose); tachycardia

Q

trazadone (mechanism of action)

A

HT2A/2C antagonist + SSRI

Q

trazadone (indication)

A

anxiety/depression

Q

trazadone (side effect)

A

suicidality early after initiation