Sympathomimetics Flashcards
(42 cards)
Name the Direct sympathomimetics
Albuterol, salmeterol, terbutaline Dobutamine Dopamine Epinephrine Fenoldopam Isoproterenol Midodrine Mirabegron Norepinephrine Phenylephrine
What receptors are activated by Albuterol, salmeterol, terbutaline?
β2 > β1
What HEMODYNAMIC CHANGES have Albuterol, salmeterol, terbutaline?
↑ HR (little effect)
What clinical APPLICATIONS Albuterol has?
Albuterol for Acute asthma/COPD.
What clinical APPLICATIONS Salmeterol has?
Salmeterol for Serial (long-term) asthma/COPD.
What clinical APPLICATIONS Terbutaline has?
Terbutaline for acute bronchospasm in asthma and tocolysis.
What RECEPTORS are activated by Dobutamine?
β1 > β2, α
What HEMODYNAMIC CHANGES have Dobutamine?
↔︎/↓ BP, ↑HR, ↑CO
What clinical APPLICATIONS Dobutamine has?
Heart failure (HF), cardiogenic shock (inotropic > chronotropic), cardiac stress testing.
What RECEPTORS are activated by Dopamine?
D1 = D2 > β > α
What HEMODYNAMIC CHANGES have Dopamine?
↑BP (high dose), ↑HR, ↑CO
What clinical APPLICATIONS Dopamine has?
Unstable bradycardia, HF, shock; inotropic and chronotropic effects at lower doses due to β effects; vasoconstriction at high doses due to α effects.
What RECEPTORS are activated by Epinephrine?
β > α
What HEMODYNAMIC CHANGES have Epinephrine?
↑BP (high dose), ↑HR, ↑CO
What clinical APPLICATIONS Epinephrine has?
Anaphylaxis, asthma, open-angle glaucoma;
α effects predominate at high doses.
Significantly stronger effect at β2-receptor than norepinephrine.
What RECEPTORS are activated by Fenoldopam?
D1
What HEMODYNAMIC CHANGES have Fenoldopam?
↓BP (vasodilation), ↑HR, ↑CO
What clinical APPLICATIONS Fenoldopam has?
Postoperative hypertension, hypertensive crisis.
Vasodilator (coronary, peripheral, renal, and splanchnic).
Promotes natriuresis.
Can cause hypotension and tachycardia.
What RECEPTORS are activated by Isoproterenol?
β1 = β2
What HEMODYNAMIC CHANGES have Isoproterenol?
↓BP (vasodilation), ↑HR, ↑CO
What clinical APPLICATIONS Isoproterenol has?
Electrophysiologic evaluation of tachyarrhythmias.
Can worsen ischemia.
Has negligible α effect.
What RECEPTORS are activated by Midodrine?
α1
What HEMODYNAMIC CHANGES have Midodrine?
↑BP (vasoconstriction), ↓HR, ↔︎/↑ CO
What clinical APPLICATIONS Midodrine has?
Autonomic insufficiency and postural hypotension.
May exacerbate supine hypertension.
