Muscarinic antagonists

Question 1

Used in the Eye.

Produce mydriasis and cycloplegia.

Answer 1

Atropine,
homatropine,
tropicamide

Question 2

CNS
Used for Parkinson disease (“park my Benz”).
Acute dystonia.

Answer 2

Benztropine,

trihexyphenidyl

Question 3

GI, respiratory
Parenteral: preoperative use to reduce airway secretions.
Oral: drooling, peptic ulcer.

Answer 3

Glycopyrrolate

Question 4

GI

Antispasmodics for irritable bowel syndrome.

Answer 4

Hyoscyamine,

dicyclomine

Question 5

Respiratory

COPD, asthma (“I pray I can breathe soon!”).

Answer 5

Ipratropium,

tiotropium

Question 6

Genitourinary

Reduce bladder spasms and urge urinary incontinence (overactive bladder).

Answer 6

Oxybutynin,
solifenacin,
tolterodine

Question 7

CNS

Motion sickness.

Answer 7

Scopolamine

Question 8

Muscarinic antagonist. Used to treat bradycardia and for ophthalmic applications.

Answer 8

Atropine

Question 9

Effects of atropine in the Eye

Answer 9

 ↑ pupil dilation, cycloplegia

Question 10

Effects of atropine in the Airway

Answer 10

Bronchodilation,  ↓secretions

Question 11

Effects of atropine in the Stomach

Answer 11

↓ acid secretion

Question 12

Effects of atropine in the Gur

Answer 12

↓motility

Question 13

Effects of atropine in the Bladder

Answer 13

↓urgency in cystitis

Question 14

Atropine ADVERSE EFFECTS

Answer 14

↑body temperature (due to  sweating);
↑HR;
dry mouth; 
dry, flushed skin; 
cycloplegia;
constipation; 
disorientation
Can cause acute angle-closure glaucoma in elderly (due to mydriasis), 
urinary retention in men with prostatic hyperplasia, 
and
hyperthermia in infants.