sympathetic nervous system 1 Flashcards
how many isoforms does an alpha adrenoreceptor
2
how many isoforms does an beta adrenoreceptor
3
what do all adrenoreceptors have in common
they are all g protein linked
why is the alpha 2 adrenoreceptor located presynaptically
feedback inhibition to inhibit noradrenaline
what does b1 adrenoreceptor lead to
hint - 4 things, fight or flight
cardiac acceleration
lipolysis
decreased gut motility
renin release
what does the b2 adrenoreceptor lead
hint - 3 things, rest and digest
vasodilation
bronchodilation
glycogen breakdown
what is the main b adrenoreceptor and what is it
propanolol
non-elective beta-blocker, local anaesthetic action
what are the two substartes of acetyl choline
choline and acetylCoA
what is the enzyme for acetylcholine synthesis
choline acetyltransferase
as well as acetylcholine, what side product is made from acetylcholine synthesis
CoA
how is acetylcholine taken up into the presynaptic vesicles and what kind of process is this
by a vesicle acetylcholine transporter
this is an active process
what molecule can block acetylcholine vesicle uptake
vesamicol
when is acetylcholine released
when calcium enters the presynaptic vesicle
how can we inactivate acetylcholine
acetylcholinesterase is in the synaptic clef and it breaks it up into choline and acetic acid and then the choline is moved back into the presynaptic nerve via a transporter
what molecule blocks choline uptake through the transporter
hemicholinium
when Ach acts on muscarinic receptors what happens
parasympathetic action
what can Ach treat when it acts on muscarinic receptors
glaucoma
what does m1, m2 and m3 receptors work on
-neural
-cardiac
-glandular
what do all muscarinic receptors have in common
they are all g coupled
