syhpilis Flashcards
rubella IgM positive
distinguish between primary infection & reinfection with rubella vaccine virus by IgG avidity assay in pregnant women
avidity
strength in which a multivalent Ab binds a multivalent Ag
ulcerative infections
-syphilis does not hurt
-herpes does hurt
-both genital ulcers
frequency of genital ulcer infections
HSV > syphilis > chancroid
-chancroid is rare
herpesviruses
large, enveloped DNA viruses
HSV
-common cold sores
-can be neonatal or congenital
-risk of transmission is with primary maternal infection at the time of delivery
-risk smaller with recurrent herpes at time of delivery
VZV
chickenpox & shingles
HHV-6
-primary target of infection is T cells
prevention of neonatal herpes
-recognition
-elective section in primary herpes at term of <4 hours after membrane rupture
-elective selection when recurrent genital herpes is present at term
syphilis infection
-treponema pallidum (spirochete)
-sexually transmitted
-placental transmission >6 weeks gestation (mostly second half of pregnancy). mom with primary or secondary syphilis more likely to transmit
syphilis neonatal clinical manifestations
fetal: still birth, neonatal death, hydrops fetalis
-intrauterine death 25%
-perinatal mortality in 25-30% if untreated
early congenital syphilis manifestation
-1st 5 weeks
-cutaneous lesions (palms/soles)
-HSM
-jaundice
-anemia
-snuffles
-periostitis & metaphysical dystrophy (bone abnormality)
-funisitis
late congenital syphilis manifestations
-frontal bossing
-short maxilla
-high palatal arch
-hutchinson teeth (sharp)
-8th nerve deafness
-saddle nose
-perioral fissures
RPR/VDRL
nontreponemal test
-sensitive but not specific
-quantitative, can follow up to monitor treatment treatment
-all pregnant women get screened early & at term
MHA-TP/FTA-ABS
specific treponemal
-confirmatory testing
-qualitative, once positive always positive