HBV

Question 1

Abs present during acute infections

Answer 1

Anti-core IgM

Question 2

Abs present during chronic infection

Answer 2

IgG
Anti-core IgG

Question 3

active replication Ag

Answer 3

HepBeAg

Question 4

immunized people & people with previous infection & had an effective immune response will have:

Answer 4

-negative HBsAg and HBeAg
-positive anti-HBv core IgG
-positive anti-HBV surface Ab (IgG) & anti-HBVeAb

Question 5

Hep B & Hep C associated with increased risk of:

Answer 5

hepatocellular cancer
-most common cause of liver cancer & liver transplantation

Question 6

hep B virus info

Answer 6

-prototype member of hepadnavirus
-circular DNA genome
-8 phenotypes

Question 7

hepadnaviridae

Answer 7

partially ds-DNA virus

Question 8

HBsAg

Answer 8

-stimulates protective Abs
-marker for current infection
-peaks ~12 weeks
-

Question 9

HBcAg

Answer 9

-localized within liver cells
-identifies acute infection
-anti-HBcAg persists for life & is marker for past infections

Question 10

ABeAg

Answer 10

marker of active replication & infectivity

Question 11

cause of hepatocellular necrosis

Answer 11

-body’s reaction to the virus rather than the virus itself
-pts with severe illness from HBV are more likely to clear the virus
-progress to chronic, longstanding infection

Question 12

HBsAg diagnostic

Answer 12

-surface protein of HBV- high levels in serum during acute or chronic infection
-presence = infectious
-Abs against HBsAg are produced normally in immune response to HBV
-used to make hep B vaccine

Question 13

prozone phenomena

Answer 13

-window period of HBV, neither HBsAg or its antibody (HBsAb) can be detected in pt serum
-due to precipitation of Ag-Ab complexes in their cones of equivalence & removed from circulation
-tests during