sweet's syndrome

Question 1

what is the other name for sweet’s syndrome (SS)

Answer 1

acute febrile neutrophilic dermatosis

Question 2

there are 5 major subtypes

Answer 2

(1) classic (2) cancer-associated (3) IBD (4) drug-induced (5) pregnancy

Question 3

what are the causes for cancer-associated and drug induced SS

Answer 3

(1) AML; (2) G-CSF, GM-CSF, ATRA, Bactrim, minocycline, OCPs, Furosemide, hydralazine

Question 4

clinical features

Answer 4

tender, burning, red, juicy papules/plaques on the head, neck, and upper extremities; rapid onset; ULCERATIVE, BULLOUS, AND ORAL LESIONS have an a/w cancer

Question 5

extracutaneous features

Answer 5

fever, leukocytosis, arthralgia/arthritis, ocular involvement

Question 6

pathology

Answer 6

diffuse dermal neutrophilic infiltrate w/ karyorrhexis, papillary dermal edema

Question 7

Tx

Answer 7

systemic steroids; resolves within 2-3 months w/o scarring; may recur in 1/3 of patients

Question 8

marshall syndrome

Answer 8

rare pediatric disease that has sweet’s like lesions that resolve w/ acquired cutis laxa at affected sites

Question 9

neutrophilic dermatosis of the dorsal hands

Answer 9

clinically resembles PG and Sweet’s syndrome. ulcerative plaques on dorsal hands. Rx prednisone, dapsone

Question 10

PG and SS exist on a spectrum

Answer 10

both + for pathergy. Pathergy is the term used to describe hyper-reactivity of the skin that occurs in response to minimal trauma.

Question 11

which types of sweet’s syndrome has an association with cancer

Answer 11

ULCERATIVE, BULLOUS, AND ORAL LESIONS

*not unlike bullous PG was a/w heme cancer too