susceptibility to periodontal diseases

Question 1

what is susceptibility

Answer 1

the state of being easilt affected, influenced, or harmed by doing something

Question 2

how susecptible are people to periodontal disease

Answer 2

10%: rapid
80%: moderate
10%: none

Question 3

what is needed for periodontal diesase to exist

Answer 3

Environment
host
perio tissues

Question 4

do all forms of periodontitics have the same etiologic factors

Answer 4

no

Question 5

what is the roll of bacteria in periodontal inflammation

Answer 5

activates the mechanism, but is not the whole picture

Question 6

what determines the tisue changes that occur because of periodontal inflammation

Answer 6

bacterial
genetics
envionental modifiers

Question 7

what are the important modifiers for perio disease

Answer 7

Smoking

Diabetes

Question 8

what is a complex gene disorder

Answer 8

multiple genes plus lifestyle and environment leads to disorder

Question 9

what kind of disease are most disease

Answer 9

Complex gene disorders

Question 10

what is polymorphisms

Answer 10

when 2+ different phenotypes exist within different individuals within the smae population

Question 11

what is polymorphism in refernce to genetics

Answer 11

region of genome that varies between individual members of the population in such proportions that the rarest of them cannot be maintained just by recurrent mutation

Question 12

what are SNP

Answer 12

single nucleotide polymorphisms

Question 13

what is the most common type of genetic variation

Answer 13

SNP

Question 14

how often do SNP’s occur

Answer 14

once in ever 300 nucleotides

Question 15

what interactions occur in complex genetic disorders

Answer 15

Multifactorial (polygenic) interaction
gene- gene interaction
gene-envirnoment interaction

Question 16

characteristics of complex genetic traits

Answer 16

Common in population
no clear familial transmission
adult onset
environmental factors are etiologic
combo of multiple small genetic and environmental factors

Question 17

how can genetics act of periodontitis

Answer 17

Structural defects (mucosa, collagen)
immune response defects (cytokines)
white blood cell defects (neutrophils, macrophages)

Question 18

how can we test for susceptibility

Answer 18

can’t test for it, must treat all people as suseptible