Surgical management of lung cancer Flashcards

1
Q

can tumours survive in hypoxic environment?

A

yes

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2
Q

what information on lung cancer staging can you get from a CXR?

A
  • pleural effusion
  • chest wall invasion
  • phrenic nerve paralysis
  • collapsed lobe or lung
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3
Q

what information on lung cancer staging can you get from a blood test?

A
  • anaemia
  • abnormal LFTs (liver function test)
  • abnormal bone profile
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4
Q

what information on lung cancer staging can you get from a CT?

A
  • size of tumour
  • mediastinal nodes
  • metastatic disease- other parts of lungs, liver, adrenals, kidneys
  • proximity to mediastinal structures
  • pleural/ pericardial effusion)
  • diaphragmatic involvement
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5
Q

what information on lung cancer staging can you get from a MRI?

A

degree of vascular and neurological involvement in Pancoast tumour

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6
Q

what information on lung cancer staging can you get from a bone scan?

A

good test for chest wall invasion and for bony metastases

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7
Q

what information on lung cancer staging can you get from ECHO?

A

demonstrates presence or absence of significant pericardial effusion

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8
Q

what do you check in the CVS to clear a patient for surgery?

A

angina, heart problem, HBP, DM, PVD, smoking, stroke/ TIA, carotid bruits, pre CABG/ angioplasty, heart murmurs

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9
Q

what do you check in the respiratory system to clear a patient for surgery?

A

barrell-chested, COAD, still smoking, asthmatic, recent URTI, on oxygen, exercise capacity, previous thoracotomy or ICD

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10
Q

what psychiatric information do you check to clear a patient for surgery?

A

PH of mental illness, severe anxiety, social background, chronic pain problems

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11
Q

what other information needs to be checked before clearing a patient for surgery?

A

pulmonary hypertension, permanent tracheostomy, rheumatoid arthritis, the immobile patient, cirrhosis history of radiotherapy to chest

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12
Q

how do you check the respiratory system for fitness for surgery? (what tests)

A
  • spirometry
  • diffusion studies
  • ABG on air/ SLV
  • fractionated V/Q scan
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13
Q

how do you check the CDV system for fitness for surgery? (what tests)

A
  • ECG
  • ECHO
  • CT scan
  • ETT
  • coronary angiogram
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14
Q

if in doubt on any of these, do you operate?

A

no

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15
Q

what are the objectives of lung cancer treatment?

A
  • curative resection
  • remove the minimum amount of lung tissue
  • resection of parietal structures is feasible
  • firm diagnosis of malignancy is highly desirable before lung resection
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16
Q

what are the reasons for peri-operative death?

A
  • ARDS
  • bronchopneumonia
  • myocardial infarction
  • PTE
  • pneumothorax
  • intrathoracic bleeding
17
Q

what are the other complications possible (none-fatal)?

A
  • post thoracotomy wound pain
  • empyema
  • BPF
  • wound infection
  • AF
  • MI
  • post-op respiratory insufficiency
  • gastroparesis/ constipation
18
Q

what are the commonest problems when assessing stage of lung cancer?

A
  • collapse of a lobe or lung makes tumour size difficult to assess
  • presence of another (usually small) pulmonary nodule
  • retrosternal thyroid
  • adrenal nodule
  • CT head is not routinely performed pre-op
19
Q

what is the % of operative mortality with pneumonectomy?

A

8-12%

20
Q

what is the % of operative mortality with lobectomy?

A

3-5%

21
Q

what is the % of operative mortality with wedge resection?

A

2-3%

22
Q

what is the % of operative mortality with open/close thoracotomy?

A

5%

23
Q

what is the 5 year post-surgery survival rate for a T1N0?

A

70%

24
Q

what is the 5 year post-surgery survival rate for a T2N0?

A

60%

25
Q

what is the 5 year post-surgery survival rate for a T3N0?

A

50%

26
Q

what is the 5 year post-surgery survival rate for a T1N1/T2N1?

A

40%

27
Q

what is the 5 year post-surgery survival rate for any T2?

A

16%

28
Q

what is the 5 year post-surgery survival rate for a patient likely to have a second primary?

A

5%

29
Q

what may look like a cancer and isn’t one?

A
  • infections: TB, lung abscesses
  • benign tumour: hamartoma
  • granuloma: sarcoid, Wegener’s, rheumatoid nodule, inflammatory pseudotumour
  • fibrosis: PMF, organising pulmonary infarct
  • other: paraffinoma