Surg Flashcards
Mustarde rotation flap
Cheek rotation flap
Acute side effects of ray
Radiodermatitis: erythema dry desquamarion and moist desquamatoon
Mucositis
Chronic side effects from ray
Atrophy Loss of appendages: alopecia and anhidrosis Hyper or hypo pigmentation Telangiectasia Ulceration
Secondary malignancy 1/1000-2000 risk, average 24 years later: BCC SCC AFX MFH fibrosarcoma angiosarcoma
List all possible treatment of cutaneous tumors
Mohs Excision Cryotherapy Radiation therapy C&C Intralesional interferon, 5-fu, methotrexate PDT Ablative laser Topical 5FU and ingenol and imiquimod Vidmodegib
Normal bread loafing of histo examines what % of tumour margins
Less than 1%
5 year cure rate mohs vs excision
Mohs 99%
Conventional 93%
5 year cure rate for recurrent cancers Mohs vs excision
Mohs 95%
Excision 80%
Cancers on ear make up what % of cutaneous cancers
6% but high recurrences likely due to embryonic fusion planes
Post auricular tumors spread where
The ear
Pre auricular tumors spread where
Towards the tragus and medial and superior aspects of the helix. Once at tragus can spread down the external part of tragus between tragar cartilage and parotid gland to deeper like facial nerve
Which site most common recurrence for BCC
Nose
Indications for Mohs
Recurrent Positive margin High risk for recurrence or mets Sites that require tissue conservation Embryonic fusion planes: peri orbital (medial canthi), nasal, lips, ears, retroauricular sulcus, melolabial folds Poorly defined clinical margins PNI >2 cM Immunosuppressed Previous ray treatment Demonstrated biological aggressiveness
Sites where tissue conservation is important
Eyelids Ears Nose Lips Digits Hails Genitalia
Best site for cure rate for Mohs on penis
Glans or prepuce, <1 cm
Supplements that make you bleed
Vitamin E
Gingko biloba
Garlic
Ways to identify where the tumour is on the skin
Magnification Dermoscopt Woods light Curette lightly Ask patient
What angle do you have blade in Mohs
30-45 degrees
What kind of specimen is best in Mohs
Saucer shaped with 30 degree beveled edges so it can be flattened
What size specimen can fit on a microscope slide
0.5-1.5 cm
How do you number the edges of tissue specimens in Mohs
Clockwise, starting at one o clock
How is a Mohs specimen cut
Horizontal sections from the deep surface first
What do you freeze Mohs specimens with
Tetrafluorethylchloride
Liquid nitrogen
What intervals of sections are sliced in Mohs
4-8 um
What stains do you use in Mohs
After sliced, stain with H&E, sometimes toludine blue
After gone through slide drainer than rinse and use a clear mounting medium: Cytosdal-60 or similar
Other stains to help with diagnosis
MART1
Cytokerstin
CD34 for DFSP
What % of tissue shrinkage from frozen section processing
10-20
If tumour involved eyelid margin how should you protect the eye
Lubricated plastic eye shield after topical Anaesthetia of tetracain Ophthal drops
Which instruments are good for perinocular excisions
Castro Viejo needle driver
Westcott scissors
Patients with high risk of IE who need prophylactic abx
Prosthetic cardiac valve
Previous IE
Unrepaired CHD or repaired with prosthetic within 6 m of procedure
Repaired CHD with residual defects
Cardiac transplant recipients with valvulopathy
Patients at high risk of joint infection
Joint replacement within last 2 years Previous prosthetic joint infection Immunocompromised T1 DM HIV Malignancy Malnourishment Haemophilia
Sites of high risk of surgical infection
Wedge on lip or ear Genitalia Below knee Skin flap on nose Skin grafts Extensive inflammatory disease
Aldabra response rates for BCC
Superficial 87%
More invasive 65%
BCC most important predictor of sub clinical spread a part from agresiva histo
> 2.5 cm
BCC margins excision versus Mohs
<2 cm 4 mm margin clears 95% in excision
Mohs <1 cm 99.9%, 1-2 cm 99.3%, 2-3 98 and >3 84.3
Recurrent BCC excision versus Mohs
Excision 12.1% recurrent at 5 years
Mohs 2.4%
Facial BCC excision versus Mohs
Mohs 2.5
Excision 4.1
Basosquamous recurrent Mohs versus excision
Mohs 4.1
Excision 12-45
What % of BCC become metastatic
<0.5%
Biologically aggressive SCCs
Cystic
Clear cell carcinoma
Adenoid SCC
Spindle cell SCC
Risk of PNI in SCC
<2.5 cm 11 %
>2.5 cm 64%