Surface Markers on T and B Cells Flashcards
Involved in T cell activation
CD2
Associated with T cell antigen receptor; role
in T cell receptor transduction
CD3
Co-receptor for MHC II; receptor for HIV
CD4
Positive or negative modulation of T and B cell receptor signaling
CD5
Co-receptor for MHC I
CD8
Protease; a marker for pre-B common acute
lymphocytic antigen (CALLA)
CD10
Low-affinity Fc receptor mediates phagocytosis and ADCC
CD16
Part of B cell co-receptor, signal transduction molecule that regulates B
cell development and activation
CD19
Receptor for complement component C3d;
part of B cell co-receptor with CD19
CD21
Regulation of IgE synthesis; triggers the release of GM-CSF from monocytes
CD23
Receptor for IL-2
CD25
Adhesion molecule mediating homing to
peripheral lymphoid organs
CD44
Essential in T and B cell antigen-stimulated
activation
CD45R
Not known function
(NK cells, subsets of T cells)
CD56
Subunit of NKG2-A complex involved in inhibition of NK cell cytotoxicity
(NK cells, subsets of T cells)
CD94
Thymocytes, T cells, NK cells
CD2
Thymocytes, T cells
CD3
Helper T cells, monocytes, and macrophages
CD4
Mature T cells, thymocytes, a subset of B cells (B1)
CD5
Thymocyte subsets, cytotoxic T cells
CD8
B and T cell precursors, bone marrow, stromal cells
CD10
Macrophages, NK cells, neutrophils
CD16
B cells, follicular dendritic cells
CD19
B cells, follicular dendritic cells, a subset of immature thymocytes
CD21
B cells, monocytes, follicular dendritic cells
CD23
Activated T, B cells, monocytes
CD25
Most leukocytes
CD44
Different forms on all hematopoietic cells
CD45R
