Interleukins Flashcards
Acts on the hypothalamus to cause fever
Interleukin 1 Alpha & Beta
Proliferation of activated B cells and T cells: IL-2 and IL-2R synthesis in T cells; Acute Phase Reactant (APR) protein synthesis in hepatocytes; cytotoxicity of natural killer (NK) cells; induction of IL-6, IFN-β, and GM-CSF
Interleukin 1 Alpha & Beta
Proliferation of activated T and B cells, stimulation of Lymphokine-activated killer (LAK) cells, cytotoxicity of NK cells
(T cells)
Interleukin 2
Differentiation of hematopoietic stem cells, mast cells
(T cells)
Interleukin 3
Growth factor for T cells, mast cells, macrophages, proliferation of B cells; class-switching by B cells
Interleukin 4
B cell growth factor I
Interleukin 4
B cell growth factor II
Interleukin 5
B cell differentiating factor
Proliferation of activated B cells, eosinophils
Interleukin 5
Differentiation of B cells, hematopoietic precursors Induction of acute-phase proteins
Interleukin 6
Stimulates B cells to plasma cells; antibody production
Interleukin 6
Proliferation of pre-B, pre-T, and activated mature T cells
Bone marrow (stromal cells)
Interleukin 7
Chemotaxis and activation of neutrophils: chemotactic for T cells
Interleukin 8
Growth of activated CD4+ T cells; proliferation of mast cells
Interleukin 9
Potent suppressor of macrophage functions
Interleukin 10
Induction of acute phase reactants
(Bone marrow stromal cells)
Interleukin 11
Activates NK cells
(T cells)
Interleukin 12
Inhibit the release of inflammatory cytokines
(T cells)
Interleukin 13
Induces proliferation of activated B cells
(T cells)
Interleukin 14
Macrophages
Monocytes
Endothelial cells
Interleukin 1 α
Fibroblasts
Epithelial cells
Interleukin 1 β
CD4+ T cells
Bone marrow stroma
Interleukin 4
CD4+ T cells
Mast cells
Interleukin 5
CD4+ T cells
Macrophages
Fibroblasts
Interleukin 6
Monocytes
Macrophages
Interleukin 8
CD4+ T cells
Interleukin 9
T cells
Macrophages
Interleukin 10
