Interleukins Flashcards
Acts on the hypothalamus to cause fever
Interleukin 1 Alpha & Beta
Proliferation of activated B cells and T cells: IL-2 and IL-2R synthesis in T cells; Acute Phase Reactant (APR) protein synthesis in hepatocytes; cytotoxicity of natural killer (NK) cells; induction of IL-6, IFN-β, and GM-CSF
Interleukin 1 Alpha & Beta
Proliferation of activated T and B cells, stimulation of Lymphokine-activated killer (LAK) cells, cytotoxicity of NK cells
(T cells)
Interleukin 2
Differentiation of hematopoietic stem cells, mast cells
(T cells)
Interleukin 3
Growth factor for T cells, mast cells, macrophages, proliferation of B cells; class-switching by B cells
Interleukin 4
B cell growth factor I
Interleukin 4
B cell growth factor II
Interleukin 5
B cell differentiating factor
Proliferation of activated B cells, eosinophils
Interleukin 5
Differentiation of B cells, hematopoietic precursors Induction of acute-phase proteins
Interleukin 6
Stimulates B cells to plasma cells; antibody production
Interleukin 6
Proliferation of pre-B, pre-T, and activated mature T cells
Bone marrow (stromal cells)
Interleukin 7
Chemotaxis and activation of neutrophils: chemotactic for T cells
Interleukin 8
Growth of activated CD4+ T cells; proliferation of mast cells
Interleukin 9
Potent suppressor of macrophage functions
Interleukin 10
Induction of acute phase reactants
(Bone marrow stromal cells)
Interleukin 11
