Supranuclear Disorders - Miriam Flashcards
what is the higher centre responsible for?
calculates type of movement and degree of movement required
what are the 6 areas that are part of the higher centre control areas?
Primary visual cortex (PVC)
Frontal eye fields (FEF)
Parieto occipital cortex (POC)
Supplementary eye fields (SEF)
Cerebellum
Superior colliculus (SC)
what do the blue and red lines indicate in the image?
saccades= red
smooth pursuit=blue
what are brainstem generator nuclei responsible for?
delivering activity to the ocular motor neurones (III,IV,VI)- controlling which muscles in eye will ‘fire’
which one of the brainstem generator nuclei are responsible for H saccades?
Para pontine reticular formation (PPRF)
what is the Rostral interstitial nucleus of the medial longitudinal fasciculus (riMLF) responsible for?
-V saccades
-Bilateral control
what is the Mesencephalic Reticular Formation (MRF) responsible for?
vergence
what is the Medial vestibular nucleus responsible for?
Vestibular Ocular Reflex
Smooth Pursuit
3 categories of Brainstem oculomotor anomalies?
- Supranuclear Above 3 nuclei so defect to one of the higher centres or one of brainstem generators.
- Internuclear : mlf defect- runs through all 3 nuclei.
- Infranuclear : Below 3 nuclei - these are actual nerves (nerve palsies).
what is the internuclear part of the brainstem also referred to?
MLF
List the 5 types of eye movements
- Saccades
- Smooth pursuit
- Vergence
- Vestibular ocular
- Optokinetic
How does a voluntary saccade occur?
via the frontal eye field
How does a reflexive Saccade occur?
via the parietal eye field
What are the steps of a normal horizontal saccadic movement to move to the left?
- Right FEF (voluntary saccade) or Right PEF (reflexive saccade)
- Left PPRF stimulates left abducens nucleus (VI)
- Abducens nucleus contains abducens motor neurones which innervate left LR
- Abducens nucleus also contains abducens internuclear neurones with axons that project via MLF to innervate the contralateral oculomotor nucleus
- Oculomotor nucleus contains motor neurones which innervate right medial rectus. due to herrings law
Patient look to the left
In a normal H saccadic movement, why would a left oculormotor nucleus contain motor neurones which innervate the right MR and cause it to contract?
Due to Herrings Law
who first described Congenital Ocular Motor Apraxia
Saccadic Initiation Failure (SIF)?
Cogan
how quickly do parents notice problems in Congenital Ocular Motor Apraxia Saccadic Initiation Failure (SIF)? what do parents notice?
Problems noticed from a few months old:
1. History: parents note an apparent lack of attention & question vision problem
2. Maybe associated with delayed walking/talking or other neurological problems- milestone problems
what eye movements are affected in Congenital Ocular Motor Apraxia
Saccadic Initiation Failure (SIF)? and what stays normal?
- Affects horizontal voluntary gaze (saccades)
(Vertical gaze usually normal)
What is Acquired ocular motor apraxia?
- Inability to do voluntary saccades- have some ability to do reflexive saccades
- Difficulty making horizontal & vertical saccades to command
Are V saccades usually affected in congenital or acquired motor apraxia?
Acquired
Are H saccades usually affected in congenital or acquired motor apraxia?
Congenital and Aquired
what are associated diseases to Aquired oculor motor apraxia?
- Huntington’s disease
- Multiple sclerosis
- Wilson’s disease (build up of copper in the body)
- Iatrogenic (aortic surgery)
- Damage possibly occurs in the frontal eye field parietal cortex
what are some characteristics of congenital OM apraxia?
1.Head thrusts- to change fixation (VOR)
2.Eye movement follows head movement until target fixated
3.Head then moves slowly back to mid line
4.Repetitive blinking - to BREAK fixation
why would a child use head thrusts in congenital OM apraxia?
to CHANGE fixation. If the head moves to the left the eyes will move to the right
why would a child use BLINKS in congenital OM apraxia?
to BREAK fixation
Do head thrusts increase or decrease as the child gets older? why?
Decrease- child develops better coping mechanisms
What is smooth pursuit palsy?
1.Loss of smooth pursuit (very rare)
- Using series small amplitude saccades (cog-wheel). Looks jerky
What causes a smooth pursuit palsy?
Aneurysm or tumour at the parietal-occipital lobe.
What is vergence system failure?
- Convergence paralysis
- Divergence paralysis
- Spasm of the near reflex
Is spasm of the near reflex to do with convergence or accommodation?
Both
What occurs/happens in convergence paralysis
- Fine in distance
- Head trauma
- XOT > near
What occurs/ happens in divergence paralysis?
Stroke or head trauma
SOT > distance
Why exotropia in convergence and esotropia in divergence paralysis?
Convergence: the eyes should be moving in. The eyes move out instead = exo
Divergece : the eyes should be moving out. The eyes move in instead = Eso
what occurs/happens in spasm of the near reflex?
- Pupil miosis
- Accommodative spasm
- Convergence
- This is psychogenic in nature
Does the optokinetic system use saccades or smooth pursuits?
Both
intact pursuit system (slow phase)
Intact saccadic system (fast phase)
What does failure of the vesitbular system result in?
Skew deviation