Suppositories Flashcards
Estrogen and prostaglandin
Work best as systemic drugs than as oral drugs
Fatty bases
Company butter, adeps solids
Water bases
Macrogols and glycero gelatin
Cocoa butter
Tri gyceride , yellowish white in colour ,brittle, and smells like chocolate
Cocoa butter
At temp. Of 15°C to 25°C, it is a hard amorphous solid, but at 30° to 35°C it melts to a bland
Cocoa butter
Low water absorptive ability but can be increased by adding surfactants as cholesterol 2% emulsifying wax up to 10% polysorbate 5 to 10% or wool fat 5 to 10%
Synthetic bases
Unaffected by heating.
Synthetic bases
Fluid than cocoa butter when melted: hence, drug sedimentation is great
Glycerol gelatin
Mixture of water and glycerol made stiff by adding gelatin
Glycerol gelatin
Good for suppositories
Glycerol gelatin
Suppositories must be kept in a well closed container in a cool dry place since they can absorb and dissolve in atmospheric moisture
Glycero gelatin
Suppositions must be dipped in water just before use to facilitate administration
Glycero gelatin
Maybe used medicated or unmedicated
Gylcero gelatin
Usually denser than theobroma; hence, a correction factor of 1.2 must be accounted for
Gylcero gelatin
Glycerine =20%
Drug= 20%
Gelatin = 60%
Macrogols ( polyethylene glycol)
Ethylene oxide + water
Macrogols
Hardness increases with an increase in molecular weight
Macrogols
Drug release is dependent on base dissolving than melting
Macrogols
Can provide sustained effect
Preparation if suppositories
- Hand rolling and shaping
- Fusion molding
- Compression
Compression moulding of suppositories
1.Good for suppositories containing insoluble solids or thermolabile AP1
2.Cannot be used for glycero gelatin products
3. Cannot be uses if melting is an essential part of preparation
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