Monophasic Dosage Forms

Question 1

Drugs

Answer 1

Potent chemical substances that must be formulated into a drug product before use

Question 2

Dosage

Answer 2

Matrix in which the drug is found in

Question 3

Stabilizers

Answer 3

1. Antioxidant- ascorbic acid, sodium metabisuphite, EDTA

Question 4

Diluents

Answer 4

Bulk forming agents. Eg lactose.

Question 5

Colourants

Answer 5

Red- fruit flavours( Strawberry and cherry)
Yellow- Lemon
Purple- black currant, grape

Question 6

Sweetening agents

Answer 6

1. Nutritive
   2 Non- nutritive

Question 7

Nutritive sweetners

Answer 7

1. Sugar- lactose, glucose etc
2. Sugar alcohohs- ĺSor6bitol
3. Corn syrups

Question 8

Non nutitive

Answer 8

High intensity artificial - Saccharine, aspartame, sucralose.
Natural intense sweetners- thaumatin , gycyrrhizin

Question 9

Sugar-free products

Answer 9

1. Don’t contain sucrose, fructose, glucose, etc
2. May contain hydrogenated glucose syrups( maltitol, xylitol, sorbitol, etc)

Question 10

Gargles

Answer 10

To treat throat infections

Question 11

Gargles

Answer 11

Have instruction = to be diluted before ise

Question 12

Mouth washes

Answer 12

Similar to garggles, bit may be used for mouthwashes

Question 13

Throat pant

Answer 13

Used for both mouth and throat infections

Question 14

Glycerin

Answer 14

Normally used as a base because of its viscosity and sweet taste.
Adheres to mucous for a long time

Question 15

Nasal drops

Answer 15

Oily ones can cause lipoidal pneumonia

Question 16

Liniment

Answer 16

They are fluid, semi-fluid, or occasionally semisolid preparations for skin applications

Question 17

Liniment

Answer 17

Maybe alcoholic, oily solutions, or emulsions

Question 18

Liniment

Answer 18

Maybe applied on a warm dressing with brush

Question 19

Liniments

Answer 19

Must not be applied to broken skin

Question 20

Lotions

Answer 20

Applied without friction.

Question 21

Lotion

Answer 21

Maybe dabbed on the skin or applied on a suitable dressing and covered with waterproof material to reduce evaporation

Question 22

Enemas

Answer 22

Oily or aqueous solutions for rectal administration

Question 23

Collodions- applied externally with brush or rod

Answer 23

Vehicle used = alcholoh and ether
Very volatile

Question 24

Collodions

Answer 24

Vehicle evaporates leaving a protective film on the body

Question 25

Collodions

Answer 25

Pyroxylin( nitrocellulose) - film producing agent Castor oil - flexibility

Question 26

Collodions

Answer 26

Un medicated ones - for protecting small cuts and abrasions Medicated ones - long contact with skin.

Question 27

Advantages of monophasic dosage forms

Answer 27

1. Improved patient compliance because they are easy to administer 2. Faster drug absorption 3. Easy to take a dose because they are homogeneous; hence, no shaking required. 4. Simple and relatively faster to formulate.

Question 28

Disadvantages

Answer 28

1. Microbial growth because of water 2. May undergo hydrolysis and become unstable