Supplement / VITAMINS Flashcards
EAR
Estimated average requirement
Average daily nutrient intake level estimated to meet requirements of half the healthy people
Brand New supplement and Used on most healthy people during research
RDA
Recommended dietary allowance
Average intake level sufficient to meet needs of 97.5% of healthy people
AI
Adequate intake –> For infants or other Population
Average intake level assumed to be adequate based on observations or experiments
UL
Tolerable upper intake level
Highest intake level likely to pose no adverse effects to almost all people
VITAMIN D Uses are
Osteoporosis
Fall Prevention
VITAMIN D Dose for infants 0-6 months
AI 400 IU/10 mcg*
VITAMIN D Dose for infants 6-12 months
AI 400 IU/10 mcg*
VITAMIN D Dose for Children 1-3 Y and 4-8 Y
600 IU/15 mcg
VITAMIN D Dose for Adults 9-70 and Upper limit
AI 600 IU/15 mcg
UL 4000 IU/ 100 mcg
VITAMIN D Dose for Adults Above 70 and Upper limit (Also called Patient with Deficiency)
AI 800 IU/20 mcg
UL 4000 IU/ 100 mcg
Vitamin A include
Also known as Pro-Vitamin
Fruits/vegetables
Beta-carotene
Vitamin A Preformed are
Meat, poultry, dairy products, liver
Retinol –> already in active form
High doses of beta-carotene (including food sources) can turn skin
yellow–HARMLESS
Vitamin A Uses are
Eyesight
• Age-related macular
degeneration (AMD)
• Cataracts
Overdose of Vitamin A can cause
Hepatotoxicity
Retinol can cause
birth defects if taken by pregnant women (even in modestly
excessive doses) STAY UNDER UL
Labels of Vitamin A can combine
Retinol and Beta Carotene
Vitmain A and Retinol Upper level intake is
- 3,000 mcg (preformed vitamin A)
* 1 mcg RAE=1 mcg retinol
If using _______ with Vitamin A supplement we have to be cautious
Retinoids
Vitamin C uses are
Wound healing
Absorption of iron
Immune function
Side Effects of Vitamin C are
Kidney stone 1g/day.
Note: Patient with kidney stones should be cautious and not exceed 1g/day
Vitamin C upper level intake is
2g daily
Dietary intake of Vitamin C do not decrease the risk of catching a cold however ,
Prophylactic vitamin C may decrease duration by 1-1.5 days
Prophylactic vitamin C may decrease duration by 1-1.5 days Exceptions are
Chronic smokers
Elderly
Vitamin D Deficiency , insufficiency and goal limits are
Serum 25-OH vit D
– Deficient <12 ng/ml
– Insufficient 12-20 ng/ml
– Goal 30-60 ng/ml
Note: For 20-30ng/ml there is no recommendation.
Two types of Vitamin D dosing are
Ergocalciferol=D2
Cholecalciferol=D3 –> more potent
IRON is use for patients with
Iron-deficiency anemia
IRON Side effects and Non adherence reasons are
Bad Taste Nausea/vomiting Constipation Abdominal pain Dark-colored stool
IRON Dosing range is
Treatment: 100-200mg elemental iron, divided
Typically TID is due to saturation of absorption
Patient taking Antibiotics, antacids, H2 blockers and PPI’S should decrease the amount of ______ for better absorption
IRON
Iron interferes with absorption of:
Bisphosphonates
Levothyroxine
Fluoroquinolones
Tetracycline
Iron and its absorption can be increased by
Vitamin C
Vitamin B1 also known as
Thiamin
Vitamin B1 deficiency caused by
Alcohol dependence
Wernicke’s encephalopathy -> neuropathy caused by alcohol
Vitamin B1 treatment Dose is
10-300 mg
Vitamin B2 is also known ______ and its use for
Riboflavin
Uses: Cataracts 5-30mg daily and Migraines 400mg daily
Vitamin B2 side effects are
Diarrhea due to (large doses)
Vitamin B3 is also known as ______ . It uses are
NIACIN
Uses: Increases HDL (high-density lipoprotein) good cholestrol Lowers TG (triglycerides) Lowers LDL (low-density lipoprotein) BAD cholestrol
Vitamin B3 doses can be
Cholesterol 1-3g.
Vitamin B3 side effects are
Flushing Itching Headache Hepatotoxicity due to high dose greater than 1.5 gm Glucose intolerance
Vitamin B6 is also known as ______. Its is use for _____ . It side effects are ______.
Pyridoxine
Uses are Pregnancy-induced nausea/vomiting
Side effects are Sensory neuropathy if the Daily dose is greater than 200mg
Note: Keep daily dose less than 200 mg
Vitamin B6 interaction can
Decreases folic acid concentrations
Antiepileptics may decrease B6 (pyridoxine)
Vitamin B6: Pyridoxine dosing range is
10-25mg TID or QID
Vitamin B9 is also known as ______. It is used for
Folate (Folic acid)
Uses: Prevention of neural tube defects and Alcohol dependency.
Vitamin B9 (folic acid) interaction can
Folic acid can mask pernicious anemia
Folic acid may reduce the efficacy of MTX (methotrexate) used in cancer
Antiepileptics reduce folate levels
Vitamin B9 Recommended Daily allowances is
400 mcg DFE adults
600 mcg DFE during pregnancy
Vitamin B12 is also known as ______, B12 deficiency can be found in
Cyanocobalamin
– Older adults
– pt with Pernicious anemia
Vitamin B12 interactions are :
Dosing for B12 are :
PPIs, H2 receptor blockers decrease B-12 level
Longterm Metformin decreases B12 levels
Dosing: Oral formulations equivalent to IM for most people
Vitamin E’s most active form is known as _____. It is Effective for
alpha-tocopherol.
Effective for : Dementia and Age-related macular degeneration (AMD)
Side effects of VITAMIN E are
Dementia: 2000 IU/day
Increased risk of all-cause mortality and bleeding if Doses are >400 IU/day (180mg) or if taking any other anti-coagulant
Vitamin K is also known as _____. Its uses are
phytonadione
It reverses Warfarin so –> do not take it with Warfarin.
Acid Dependent Medication such as PPI, H2 can _______ Calcium Absorption. Absorption starts to become saturated at doses
decrease, greater than 500mg
Calcium RDA for
Adults 19-50 y
Men 51-70 y
Women 51-70 y
Adults >70 y
Adults 19-50 y –> 1000 mg
Men 51-70 y –> 1000 mg
Women 51-70 y –> 1200 mg
Adults >70 y –> 1200 mg
Magnesium is use to treat _____ and _____. Its Side effects are ______
uses: Constipation and Migraine
Side effects are Diarrhea
Magnesium levels decrease by certain medications that are
Proton pump inhibitors (PPIs)
Thiazide/loop diuretics
Zinc Common uses are
Common cold
Wound healing
Age-related macular degeneration
Zinc side effects are
Nausea/vomiting
– Metallic taste
Dosing for Zinc is
AMD
• Higher Dose for wound healingAERDS 80mg/day
• lower dose for common cold AERDS2 23mg/day
Zinc pyrithione is best known for its use in treating ______. Intranasal Zinc spray can cause
dandruff, anosmia
Zinc interactions with other drugs include
Cephalosporins,
fluoroquinolones,
tetracycline
They all Separate by 3 hours
What is NOT a dietary supplement?
– Prescription medications – OTC medications – Homeopathic remedies – Medical foods
What is the highest Ratio of Homeopathic remedy?
30C
DSHEA: 1994 Dietary Supplement and Health Education Act
Definition of dietary supplements
– Minimal labeling requirements
– Manufacturer is responsible for controlling quality and safety
Difference between Label of OTC and Supplement
OTC
Purpose
Uses
Warnings
Supplements Disclaimer (if using a structure/function claim)
Who will be doing supplement verfication
DSVP (Dietary Supplement Verification Program)
What FDAMA (FDA Modernization Act) 1997 does?
Encourages consumers to be more involved
Permits health claims on foods supported by federal scientific bodies
Dietary Supplement and Nonprescription Drug Consumer Protection Act 2006
Must include manufacturer information
Must notify FDA of serious adverse effects
For Supplements Labels FDA requirements are that it should have
Statement of identity Net quantity Directions Supplement Facts panel Other ingredients Manufacturer name and address Disclaimer (if using a structure/function claim)
Structure/function claims on supplement will tell
Product affects structure or function of the body
May not claim effectiveness for prevention or treatment of disease
Nutritional content claims are
– Must have an established recommended daily value like 12g etc
Health claims for supplement are
Authorized by the FDA
Describe relationship between disease or health condition and a food, diet, or dietary product
What Natural medicine website will tell us about supplements?
Interaction Checker
Nutrient Depletion
Effectiveness Checker
What NIH (NATURAL INSTITUTE OF HEALTH will tell us about supplements
They have a fact sheet in two versions (health professional and customer both version
Dictionary
Background info
botanical dietary supplement
Full List of Fact Sheet