Summary of Resistance Mechanism by Drug Class

Question 1

Examples of Beta-lactams

Answer 1

Penicillins
Cephalosporins
Carbapenems
Monobactams

Question 2

Examples of Aminoglycosides

Answer 2

Gentamycin
Tobramycin
Amikacin

Question 3

Examples of Glycopeptides

Answer 3

Vancomycin

Question 4

Examples of Lipopeptides

Answer 4

Daptomycin

Question 5

Examples of Tetracyclines

Answer 5

Doxycycline

Minocycline

Question 6

Examples of Glycylcycline

Answer 6

Tigecycline

Question 7

Examples of Macrolides

Answer 7

Erythromycin
Azithromycin
Clarithromycin

Question 8

Examples of Lincosamides

Answer 8

Clindamycin

Question 9

Examples of Streptogramins

Answer 9

Quinupristin/dalfopristin

Question 10

Examples of Oxazolidinones

Answer 10

Linezolid

Tedizolid

Question 11

Examples of Fluoroquinolones

Answer 11

Ciprofloxacin
Levofloxacin
Moxifloxacin

Question 12

Examples of Pyrimidines

Answer 12

Trimethoprim

Question 13

Examples of Sulfonamides

Answer 13

Sulfamethoxazole

Question 14

Examples of Rifamycins

Answer 14

Rifampin

Question 15

Examples of Cationic peptides

Answer 15

Colistin

Polymyxin B

Question 16

Resistance Mechanism(s) of:
Beta-lactams

Answer 16

Hydrolysis (by beta-lactamase)
Altered target site
Efflux

Question 17

Resistance Mechanism(s) of:
Aminoglycosides

Answer 17

Aminoglycoside-modifying enzymes
Altered target site
Efflux

Question 18

Resistance Mechanism(s) of:
Glycopeptides

Answer 18

Altered cell wall precursors

Question 19

Resistance Mechanism(s) of:
Lipopeptides

Answer 19

Altered target site

Thickening peptidoglycan structure

Question 20

Resistance Mechanism(s) of:
Tetracyclines

Answer 20

Altered target site

Efflux

Question 21

Resistance Mechanism(s) of:
Glycylcycline

Answer 21

Altered target site

Efflux

Question 22

Resistance Mechanism(s) of:
Macrolides

Answer 22

Altered target site

Efflux

Question 23

Resistance Mechanism(s) of:
Lincosamides

Answer 23

Altered target site

Efflux

Question 24

Resistance Mechanism(s) of:
Streptogramins

Answer 24

Acetylation
Altered target site
Efflux

Question 25

``` Resistance Mechanism(s) of: Oxazolidinones ```

Answer 25

Altered target site | Efflux

Question 26

``` Resistance Mechanism(s) of: Fluoroquinolones ```

Answer 26

Altered target site | Efflux

Question 27

``` Resistance Mechanism(s) of: Pyrimidines ```

Answer 27

Altered target site | Efflux

Question 28

``` Resistance Mechanism(s) of: Sulfonamides ```

Answer 28

Altered target site | Efflux

Question 29

``` Resistance Mechanism(s) of: Rifamycins ```

Answer 29

ADP-ribosylation Altered target site Efflux

Question 30

``` Resistance Mechanism(s) of: Cationic peptides ```

Answer 30

Altered target site | Efflux