Summary

Question 1

Most common cause of cancer related deaths in the UK?

Answer 1

lung cancer

Question 2

Most common UK cancer (excluding non melanoma skin cancer)?

Answer 2

breast cancer

Question 3

features of splenic atrophy on a blood film?

Answer 3

howell-jolly bodies-nucleic remnants in circulating erythrocytes
pappenheimer bodies (siderotic granules on iron staining)
misshapen cells

Question 4

hypersplenism characteristics?

Answer 4

enlarged spleen

reduction of at least 1 cell line in the blood in the presence of normal bone marrow function.

Question 5

causes of hyposplenism?

Answer 5

splenectomy
sickle cell disease
essential thrombocythaemia
adult gluten induced enteropathy
dermatitis herpetiformis
IBD
splenic arterial thrombosis

Question 6

diagnostic test for hereditary spherocytosis?

Answer 6

osmotic fragility test

Question 7

2 investigations performed at the haematuria clinic for patients aged 45 or over with unexplained visible haematuria and no UTI or persistence/recurrence following successful UTI treatment?

Answer 7

renal tract USS and flexible cystoscopy

Question 8

investigations for pt who presents with pancytopenia on FBC?

Answer 8

reticulocyte count
U+Es
LFTs
TFTs
vit B12 and folate-megaloblastic anaemia
infection screen-EBV, HIV, Hep C, parvovirus
blood film
BM-aspiration and trephine biospy