sulfonilureele

Question 1

reprezentantii generatii 1

Answer 1

tolbutamid
clopropamid

Question 2

denumire comerciala tolbutamid

Answer 2

tolbutamid 500

Question 3

denumire comerciala clopropamid

Answer 3

diabense 250mg

Question 4

reprezentanti generatia 2

Answer 4

glibenclamid
glipizid

Question 5

denumiri comerciale glibenclamid

Answer 5

glibenclamid 5mg
maninil 3,5,g

Question 6

denumiri comerciale glipizid

Answer 6

glucotrol 5, 10 mg
diaprel 80mg
diaprel mr 30 mg

Question 7

reprezentanti generatia 3

Answer 7

gliquidona

Question 8

denumire comerciala gliquidona

Answer 8

glurenorm 30mg

Question 9

administrare

Answer 9

initiere cu doza minima
titrare la 4-7 zile
orice alt antidiabetic afara de meglidine
se administreaza cu aprox 30 minute inainte de masa

Question 10

mecanism

Answer 10

se leaga de receptorul sulfonilureei de pe membrana celulelor beta, se inchid canalele de potasiu ATP-dependente si blocheaza fluxul de potasiu, depolarizarea favorizeaza influxul de Ca si stimuleaza eliberarea de insulina

Question 11

indicatii

Answer 11

dez2 cu glicemii pana in 250 mg% mai ales cei fara obezitate

Question 12

contraindicatii

Answer 12

dz1
sarcina, alaptare
IR
hepatopatii cronice
interventii chirugicare majore
cetoacidoza
infectii severe
IMA
alergii
peste 60 ani nu gen1

Question 13

efecte adverse

Answer 13

crestere in greutate
extinderea infarctului interfera cu preconditionarea ischemica
hipoglicemii
arsuri gastrice
greturi
anemie hemolitica
trombocitopenie
modificari ale testelor hepatice