Sulfonamides

Question 1

What is the route commonly used?

Answer 1

Oral

Question 2

What are the clinical uses for sulfonamides

Answer 2

UTIs, chlamydia, respiratory infection, bronchitis, traveler’s diarrhea, sinusitis

Question 3

What are the side effects ?

Answer 3

Allergic, fever, skin rashes, photosensitivity, GI effects, urinary tract disturbances

Question 4

What is Trimethoprim-sulfamethoxazole used for

Answer 4

UTIs, pneumocystis pneumonia; shigella infections, chronic bronchitis exacerbations

Question 5

What do sulfonamides and Trimethoprim-sulfamethoxazole do as synergists?

Answer 5

Inhibits folic acid metabolism increasing bacterial kill

Question 6

What are the common adverse effects of Trimethoprim-sulfamethoxazole

Answer 6

Nausea, vomiting, skin rash, itching, fever, photosensitivity

Question 7

What are the risks of Trimethoprim-sulfamethoxazole

Answer 7

Crystalluria, oliguria, renal failure

Question 8

What do you monitor for Trimethoprim-sulfamethoxazole

Answer 8

Agranulocytosis and thrombocytopenia

Question 9

What are the contraindications for Trimethoprim-sulfamethoxazole

Answer 9

Sulfonamide hypersensitivity; megaloblastic anemia due to folate deficiency; pregnant women at term or nursing mothers; hyperkalemia