Fluoroqinolone And Prototype Flashcards
What are the common adverse effects of fluoroquinolone
Nausea, vomiting, diarrhea, sleep disturbances, headache, dizziness
What are the serious adverse effects of fluoroquinolone
Dysrythymias, hepatotoxicity
What are the drug interactions of fluoroquinolone
Inhibits CYP 1A2 and antacids decrease absorption
What is the MOA of ciproflaxin
Inhibits bacterial DNA gyrase, affecting replication and repair and is more effective against gram - bacteria
What are the inductions of ciproflaxin
UTIs, sinusitis, pneumonia, skin, bone, and joint infections, infectious diarrhea, certain eye infections
What is the route of ciprofloxacin
PO, IV, otic, opthalmically; Prowuin XR for bladder infections
What is the administration alert for ciproflaxin
Give 4 hours before antacids or ferrous sulfate
What are the risks of ciproflaxin
Tendinitis and tendon rupture risk; has higher risk in 60> years old, kidney, heart, lung transplant recipient, and pt on corticosteroid; severe muscle weakness in myasthenia gravis
What are the contraindications for ciproflaxin
Hypersensitivity to fluoroquinolone and discontinue if tendon pain and inflammation occurs
What are the drug interactions of ciproflaxin
Increases anticoagulant risks, theophylline levels;
Antacids, ferrous sulfate, sucralfate reduce absorption
What does ciproflaxin do to lab tests
Increases ALT, AST, serum creatinine, BUN
What food/herbal interactions does ciproflaxin affect
Increases caffeine levels (anxiety, nervousness, tachycardia); and dairy products and calcium fortified drinks reduce absorption
Is there a treatment for overdose of fluoroquinolone
No
