Sulfonamide Antimicrobial Agents Flashcards
Activity of prontosil?
Inactive in vitro, prodrug in that its metabolites are active
Prontosil used to treat?
Candida albicans
What do sulfonamides competitively inhibit?
Incorporation of p-aminobenzoic acid into folic acid nucleus via inhibition of dihydropteroate synthase
Why do sulfonamides not hurt mammalian cells, but hurts bacterial cells?
Mammalian cells utilize preformed folate in the diet while bacterial cells make their own folic acid
Antibiotic activity of sulfonamides can be reversed by what?
Adding large quantities of PABA (p-aminobenzoic acid) to diet
Structure of sulfanilamide resembles what
PABA
Acidity of PABA vs sulfanilamide?
PABA pKa 6.5
Sulfanilamid pKa 10.4
What type of acid is sulfanilamide?
Weak acid
What enhanced the potency and acidified the sulfonamide nitrogen of sulfanilamide drug?
Attachment of electron withdrawing heteroaromatic rings
Increase in acidity decrease the incidence of what?
Crystalluria (Crystallization of the sulfonamide in urine resulting in kidney damage)
What do they recommend be done when taking sulfonamides to reduce crystalluria?
Drink large amounts of water
Sulfonamides in general inhibit what?
Gram + and Gram -
Nocardia
Chlamydia trachomatis
Protozoa/fungi
How are sulfonamides usually used in treatment?
In combination
Why are sulfonamides usually used in combination?
Resistance factors are too widespread
Most popular sulfonamide?
Sulfisoxazole
What are sulfisoxazole and sulfamethoxazole used to treat>
Urinary tract infections
What is used in a 1:1:1 ratio to treat Gardnerella vaginalis?
Sulfabenzamide, sulfacetamide, and sulfathiazole
What is sulfasalazine?
Prodrug not well absorbed from GI tract
What do bacteria metabolize sulfasalazine to?
Sulfapyridine and 5-aminosalicyclic acid
Function of 5-aminosalicyclic acid?
Antiinflammatory
What is sulfasalizine used to treat?
Ulcerative colitis and Chron’s disease
Why don’t we just administer 5-aminosalicyclic acid directly?
Irritating to gastric mucosa
Sulfadoxine and pyrimethamine are used together to prevent what?
Malaria
Pyrimethamine is inhibitor of what?
Plasmodium falciparum dihydrofolate preductase
First line chemotherapy to treat acute toxoplasmosis?
Sulfadiazine and pyrimethamine