Suicide Inhibition Flashcards
1
Q
It is reversible or irreversible
A
Irreversible
2
Q
Suicide Inhibtion is also known as
A
Mechanism based inactivation
3
Q
Ornithine decarboxylase catalysés conversion of
A
Ornithine to putrescine ( necessary for polyamine synthesis)
4
Q
ODC inhibited In
A
Trypanosoma
5
Q
Inhibitor of ODC effective against trypanosomiasis
A
DFMO difluoromethyl ornithine
6
Q
Allopurinol is converted to —- which inhibits xanthine oxidase
A
Alloxanthine
7
Q
Arachidonic acid is converted to prostaglandins by
A
Enzyme cyclooxygenase
8
Q
What acetylates à serine residue in cyclooxygenase inhibiting prostaglandin synthesis
A
Aspirin
9
Q
5fluoro Uracil is converted to ———— which inhibits thymidylate synthase enzyme and thus DNA synthesis
A
Fluorodeoxyuridylate
